Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | ACKR3 | P25106 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | TERT | O14746 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3603717 | 0.96 | CHRM2 (0.40) | CHRM2CHRM4CHRM1CHRM3ACKR3 | |
| SCHEMBL4059340 | 0.92 | ACKR3 (0.41) | CHRM2CHRM4CHRM1CHRM3ACKR3 | |
| SCHEMBL4062472 | 0.92 | CHRM2 (0.43) | CHRM2CHRM4CHRM1CHRM3ACKR3 | |
| SCHEMBL4056542 | 0.91 | CHRM2 (0.41) | CHRM2CHRM4CHRM1CHRM3ACKR3 | |
| SCHEMBL4056335 | 0.90 | SLC6A2 (0.48) | CHRM2CHRM4CHRM1CHRM3ACKR3 | |
| SCHEMBL4054211 | 0.90 | GPR119 (0.41) | CHRM2CHRM4CHRM1CHRM3ACKR3 | |
| SCHEMBL3612242 | 0.89 | ACKR3 (0.39) | CHRM2CHRM4CHRM1CHRM3ACKR3 | |
| SCHEMBL3608812 | 0.89 | CHRM2 (0.41) | CHRM2CHRM4CHRM1CHRM3ACKR3 | |
| SCHEMBL3601735 | 0.87 | PLK1 (0.41) | TP53GPR119MAPTSMN1; SMN2POLB | |
| SCHEMBL3603719 | 0.87 | SLC6A2 (0.46) | CHRM2CHRM4CHRM1CHRM3ACKR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2061776-A1 | ARYL SULFAMIDE DERIVATIVES AND METHODS OF THEIR USE | Wyeth a Corporation of the State of Delaware (US) | 2009-05-27 | — | — | EP | disclosed |
| WO-2008073459-A1 | ARYL SULFAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-06-19 | — | — | WO | disclosed |