Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 4/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.56 |
| ▸ | CASP7 | P55210 | 1/20 | 0.56 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 7/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.46 |
| ▸ | KAT2B | Q92831 | 2/20 | 0.45 |
| ▸ | PHGDH | O43175 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4054385 | 0.89 | MAPK1 (0.57) | MAPK1L3MBTL1ALDH1A1TDP1CASP7 | |
| SCHEMBL3571014 | 0.83 | MAPK1 (0.62) | MAPK1L3MBTL1ALDH1A1TDP1CASP7 | |
| SCHEMBL397773 | 0.82 | MAPK1 (0.77) | MAPK1L3MBTL1ALDH1A1TDP1CASP7 | |
| SCHEMBL4940492 | 0.79 | EPAS1 (0.56) | MAPK1L3MBTL1ALDH1A1TDP1CASP7 | |
| SCHEMBL4064354 | 0.79 | EPAS1 (0.59) | MAPK1L3MBTL1ALDH1A1TDP1CASP7 | |
| SCHEMBL30615510 | 0.79 | EPAS1 (0.56) | MAPK1L3MBTL1ALDH1A1TDP1CASP7 | |
| SCHEMBL22583718 | 0.77 | MAPK1 (0.51) | MAPK1L3MBTL1ALDH1A1TDP1CASP7 | |
| SCHEMBL28073238 | 0.77 | MAPK1 (0.51) | MAPK1L3MBTL1ALDH1A1TDP1CASP7 | |
| SCHEMBL4057190 | 0.77 | MAPK1 (0.59) | MAPK1L3MBTL1ALDH1A1TDP1CASP7 | |
| SCHEMBL3609055 | 0.76 | EPAS1 (0.63) | MAPK1L3MBTL1ALDH1A1TDP1CASP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2061776-A1 | ARYL SULFAMIDE DERIVATIVES AND METHODS OF THEIR USE | Wyeth a Corporation of the State of Delaware (US) | 2009-05-27 | — | — | EP | disclosed |
| WO-2008073459-A1 | ARYL SULFAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-06-19 | — | — | WO | disclosed |