Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 6/20 | 0.47 |
| ▸ | CNR1 | P21554 | 6/20 | 0.40 |
| ▸ | CNR2 | P34972 | 5/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.37 |
| ▸ | HTR3A | P46098 | 2/20 | 0.36 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13690964 | 1.00 | ROCK1 (0.47) | ROCK1CNR1CNR2KDM4CHTR3A | |
| SCHEMBL13690967 | 0.95 | ROCK1 (0.46) | ROCK1CNR1CNR2KDM4CHTR3A | |
| SCHEMBL4053150 | 0.95 | ROCK1 (0.46) | ROCK1CNR1CNR2KDM4CHTR3A | |
| SCHEMBL13690641 | 0.94 | ROCK1 (0.47) | ROCK1CNR1CNR2HTR3AGRM4 | |
| SCHEMBL4053793 | 0.94 | ROCK1 (0.47) | ROCK1CNR1CNR2HTR3AGRM4 | |
| SCHEMBL13691250 | 0.92 | CNR1 (0.49) | ROCK1CNR1CNR2KDM4CHTR3A | |
| SCHEMBL4051688 | 0.92 | CNR1 (0.49) | ROCK1CNR1CNR2KDM4CHTR3A | |
| SCHEMBL4056771 | 0.91 | CNR1 (0.41) | ROCK1CNR1CNR2KDM4CHTR3A | |
| SCHEMBL13690996 | 0.91 | CNR1 (0.41) | ROCK1CNR1CNR2KDM4CHTR3A | |
| SCHEMBL4048374 | 0.90 | ROCK1 (0.44) | ROCK1CNR1CNR2KDM4CHTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009106980-A2 | INDAZOLE DERIVATIVES | PFIZER INC. (US) | 2009-09-03 | — | — | WO | claimed |
| WO-2009106980-A2 | INDAZOLE DERIVATIVES | PFIZER INC. (US) | 2009-09-03 | — | — | WO | disclosed |