Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHBP | P24387 | 3/20 | 0.67 |
| ▸ | CRHR2 | Q13324 | 3/20 | 0.67 |
| ▸ | MYC | P01106 | 3/20 | 0.63 |
| ▸ | MAX | P61244 | 3/20 | 0.63 |
| ▸ | NPC1 | O15118 | 1/20 | 0.63 |
| ▸ | RAB9A | P51151 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.57 |
| ▸ | CISD1 | Q9NZ45 | 2/20 | 0.55 |
| ▸ | PIM1 | P11309 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.55 |
| ▸ | GSK3B | P49841 | 1/20 | 0.54 |
| ▸ | NAT1 | P18440 | 4/20 | 0.53 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.53 |
| ▸ | CLK1 | P49759 | 1/20 | 0.53 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.53 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4051639 | 1.00 | CRHBP (0.67) | CRHBPCRHR2MYCMAXNPC1 | |
| SCHEMBL4058915 | 1.00 | CRHBP (0.67) | CRHBPCRHR2MYCMAXNPC1 | |
| SCHEMBL4057695 | 1.00 | CRHBP (0.67) | CRHBPCRHR2MYCMAXNPC1 | |
| SCHEMBL4052866 | 0.89 | NAT1 (0.70) | CRHBPCRHR2MYCMAXNPC1 | |
| SCHEMBL4058656 | 0.87 | CRHBP (0.62) | CRHBPCRHR2MYCMAXNPC1 | |
| SCHEMBL4057818 | 0.87 | MYC (0.73) | CRHBPCRHR2MYCMAXNPC1 | |
| SCHEMBL4057820 | 0.87 | MYC (0.73) | CRHBPCRHR2MYCMAXNPC1 | |
| SCHEMBL4056466 | 0.86 | CRHBP (0.61) | CRHBPCRHR2MYCMAXNPC1 | |
| SCHEMBL8167434 | 0.84 | PIM1 (0.75) | CRHBPCRHR2MYCMAXNPC1 | |
| SCHEMBL8167436 | 0.84 | PIM1 (0.75) | CRHBPCRHR2MYCMAXNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009109999-A1 | NOVEL PROTEIN TYROSINE PHOSPHATASE - IB INHIBITORS | LUPIN LIMITED (IN) | 2009-09-11 | — | — | WO | disclosed |