Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 7/20 | 0.44 |
| ▸ | CNR2 | P34972 | 6/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 4/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | CFD | P00746 | 2/20 | 0.35 |
| ▸ | PLK1 | P53350 | 1/20 | 0.34 |
| ▸ | HTR3A | P46098 | 1/20 | 0.33 |
| ▸ | KDM5A | P29375 | 1/20 | 0.32 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4055448 | 0.91 | CNR1 (0.52) | CNR1CNR2HTR2AHTR2CSLC6A4 | |
| SCHEMBL4053385 | 0.90 | CNR1 (0.50) | CNR1CNR2HTR2AHTR2CSLC6A4 | |
| SCHEMBL4047930 | 0.90 | CNR1 (0.41) | CNR1CNR2HTR2AHTR2CSLC6A4 | |
| SCHEMBL13690962 | 0.90 | ROCK1 (0.43) | CNR1CNR2KDM4CROCK1HTR3A | |
| SCHEMBL4049829 | 0.90 | ROCK1 (0.43) | CNR1CNR2KDM4CROCK1HTR3A | |
| SCHEMBL13690975 | 0.90 | CNR1 (0.56) | CNR1CNR2CFDHTR3A | |
| SCHEMBL13690631 | 0.88 | CNR1 (0.40) | CNR1CNR2HTR2AHTR2CSLC6A4 | |
| SCHEMBL4051599 | 0.88 | CNR1 (0.40) | CNR1CNR2HTR2AHTR2CSLC6A4 | |
| SCHEMBL4049364 | 0.88 | CNR1 (0.42) | CNR1CNR2HTR2AHTR2CSLC6A4 | |
| SCHEMBL4050200 | 0.85 | CNR1 (0.43) | CNR1CNR2HTR2AHTR2CSLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009106980-A2 | INDAZOLE DERIVATIVES | PFIZER INC. (US) | 2009-09-03 | — | — | WO | claimed |
| WO-2009106980-A2 | INDAZOLE DERIVATIVES | PFIZER INC. (US) | 2009-09-03 | — | — | WO | disclosed |
| WO-2009106980-A2 | INDAZOLE DERIVATIVES | PFIZER INC. (US) | 2009-09-03 | — | — | WO | disclosed |