Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 5/20 | 0.52 |
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.42 |
| ▸ | CNR2 | P34972 | 2/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 7/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.35 |
| ▸ | HTR2A | P28223 | 6/20 | 0.35 |
| ▸ | GUCY1A1 | Q02108 | 2/20 | 0.34 |
| ▸ | GUCY1B1 | Q02153 | 2/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4057458 | 0.93 | CNR1 (0.52) | CNR1KDM4CCNR2ROCK1P2RX7 | |
| SCHEMBL13690583 | 0.93 | CNR1 (0.52) | CNR1KDM4CCNR2ROCK1P2RX7 | |
| SCHEMBL4052062 | 0.93 | CNR1 (0.49) | CNR1KDM4CCNR2ROCK1P2RX7 | |
| SCHEMBL4049829 | 0.92 | ROCK1 (0.43) | CNR1KDM4CCNR2ROCK1 | |
| SCHEMBL13690962 | 0.92 | ROCK1 (0.43) | CNR1KDM4CCNR2ROCK1 | |
| SCHEMBL4058358 | 0.91 | CNR1 (0.44) | CNR1KDM4CCNR2ROCK1HTR2C | |
| SCHEMBL13691249 | 0.90 | CNR1 (0.59) | CNR1KDM4CCNR2ROCK1P2RX7 | |
| SCHEMBL4050445 | 0.90 | CNR1 (0.59) | CNR1KDM4CCNR2ROCK1P2RX7 | |
| SCHEMBL4051688 | 0.89 | CNR1 (0.49) | CNR1KDM4CCNR2ROCK1P2RX7 | |
| SCHEMBL13691250 | 0.89 | CNR1 (0.49) | CNR1KDM4CCNR2ROCK1P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009106980-A2 | INDAZOLE DERIVATIVES | PFIZER INC. (US) | 2009-09-03 | — | — | WO | claimed |
| WO-2009106980-A2 | INDAZOLE DERIVATIVES | PFIZER INC. (US) | 2009-09-03 | — | — | WO | disclosed |