Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 3/20 | 0.74 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.74 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.56 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.56 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.43 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | JUN | P05412 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4058522 | 1.00 | CHRNB2 (0.74) | CHRNB2CHRNA4MEN1KMT2ACHRNB4 | |
| SCHEMBL620178 | 0.85 | CHRNB2 (1.00) | CHRNB2CHRNA4MEN1KMT2ACHRNB4 | |
| SCHEMBL2472109 | 0.85 | CHRNB2 (1.00) | CHRNB2CHRNA4MEN1KMT2ACHRNB4 | |
| SCHEMBL620444 | 0.85 | CHRNB2 (1.00) | CHRNB2CHRNA4MEN1KMT2ACHRNB4 | |
| SCHEMBL620443 | 0.85 | CHRNB2 (1.00) | CHRNB2CHRNA4MEN1KMT2ACHRNB4 | |
| SCHEMBL2472105 | 0.85 | CHRNB2 (1.00) | CHRNB2CHRNA4MEN1KMT2ACHRNB4 | |
| SCHEMBL3011080 | 0.85 | CHRNB2 (1.00) | CHRNB2CHRNA4MEN1KMT2ACHRNB4 | |
| SCHEMBL620179 | 0.85 | CHRNB2 (1.00) | CHRNB2CHRNA4MEN1KMT2ACHRNB4 | |
| SCHEMBL3025719 | 0.82 | CHRNB2 (0.68) | CHRNB2CHRNA4MEN1KMT2ACHRNB4 | |
| SCHEMBL3025722 | 0.82 | CHRNB2 (0.68) | CHRNB2CHRNA4MEN1KMT2ACHRNB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0900200-B9 | PHARMACEUTICAL COMPOSITIONS FOR PREVENTION AND TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | TARGACEPT INC (US) | 2009-10-21 | — | — | EP | disclosed |
| EP-0900200-B1 | PHARMACEUTICAL COMPOSITIONS FOR PREVENTION AND TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | TARGACEPT INC (US) | 2008-12-03 | — | — | EP | disclosed |