Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 18/20 | 0.49 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL180946 | 0.89 | DGAT1 (0.50) | DGAT1MEN1KMT2A | |
| SCHEMBL180572 | 0.86 | MEN1 (0.57) | DGAT1SOAT1MEN1NPC1ALDH1A1 | |
| SCHEMBL15445191 | 0.86 | DGAT1 (0.58) | DGAT1SOAT1 | |
| SCHEMBL13664083 | 0.86 | DGAT1 (0.58) | DGAT1SOAT1 | |
| SCHEMBL180850 | 0.86 | DGAT1 (0.58) | DGAT1SOAT1 | |
| SCHEMBL14617040 | 0.86 | DGAT1 (0.58) | DGAT1SOAT1 | |
| SCHEMBL180704 | 0.85 | DGAT1 (0.55) | DGAT1SOAT1 | |
| SCHEMBL180833 | 0.84 | DGAT1 (0.52) | DGAT1SOAT1 | |
| SCHEMBL180623 | 0.82 | DGAT1 (0.48) | DGAT1SOAT1KMT2A | |
| SCHEMBL180802 | 0.82 | DGAT1 (0.54) | DGAT1SOAT1MEN1NPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009112445-A1 | METHOD OF INCREASING CELLULAR PHOSPHATIDYL CHOLINE BY DGAT1 INHIBITION | NOVARTIS AG (CH) | 2009-09-17 | — | — | WO | claimed |
| WO-2009112445-A1 | METHOD OF INCREASING CELLULAR PHOSPHATIDYL CHOLINE BY DGAT1 INHIBITION | NOVARTIS AG (CH) | 2009-09-17 | — | — | WO | disclosed |