Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.32 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.31 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.31 |
| ▸ | PPARD | Q03181 | 1/20 | 0.31 |
| ▸ | PPARA | Q07869 | 1/20 | 0.31 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.30 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.30 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4061187 | 0.88 | PDE4A (0.31) | PDE4APDE4BPDE10ANR4A2PPARD | |
| SCHEMBL4688152 | 0.84 | CYSLTR2 (0.36) | ALOX5APFFAR4 | |
| SCHEMBL4059423 | 0.84 | CYSLTR2 (0.38) | ALOX5APFFAR4 | |
| SCHEMBL4051700 | 0.80 | CYSLTR2 (0.38) | ALOX5APFFAR4 | |
| SCHEMBL4049859 | 0.80 | CYSLTR2 (0.40) | ALOX5APFFAR4 | |
| SCHEMBL4052136 | 0.73 | CYSLTR2 (0.36) | PDE10AALOX5AP | |
| SCHEMBL4052958 | 0.72 | CYSLTR2 (0.39) | PDE10AALOX5AP | |
| SCHEMBL7806623 | 0.69 | TBXA2R (0.42) | — | |
| SCHEMBL7802326 | 0.68 | TBXA2R (0.44) | — | |
| SCHEMBL7801407 | 0.68 | TBXA2R (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7557212-B2 | Tricyclic derivatives as LTD4 antagonists | LABORATORIOS ALMIRALL, S.A. (ES) | 2009-07-07 | — | — | US | disclosed |