Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MITF | O75030 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | BLM | P54132 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | STAT6 | P42226 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4062492 | 1.00 | LMNA (0.52) | LMNASMN1; SMN2MITFKMT2AALDH1A1 | |
| SCHEMBL259014 | 0.98 | LMNA (0.50) | LMNASMN1; SMN2MITFKMT2AALDH1A1 | |
| SCHEMBL1238335 | 0.98 | LMNA (0.54) | LMNASMN1; SMN2MITFKMT2AALDH1A1 | |
| Hydrochloric Acid SCHEMBL11189351 | 0.95 | LMNA (0.52) | LMNASMN1; SMN2MITFKMT2AALDH1A1 | |
| SCHEMBL59155 | 0.91 | — | — | |
| SCHEMBL2297517 | 0.88 | LMNA (0.59) | LMNASMN1; SMN2MITFKMT2AALDH1A1 | |
| SCHEMBL1700875 | 0.88 | LMNA (0.59) | LMNASMN1; SMN2MITFKMT2AALDH1A1 | |
| SCHEMBL10871994 | 0.88 | LMNA (0.59) | LMNASMN1; SMN2MITFKMT2AALDH1A1 | |
| SCHEMBL1857819 | 0.88 | LMNA (0.59) | LMNASMN1; SMN2MITFKMT2AALDH1A1 | |
| SCHEMBL839318 | 0.88 | LMNA (0.59) | LMNASMN1; SMN2MITFKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2069347-A2 | NOVEL INHIBITORS OF BETA-LACTAMASE | Merck & Co., Inc. (US) | 2009-06-17 | — | — | EP | disclosed |
| WO-2008039420-A2 | NOVEL INHIBITORS OF BETA-LACTAMASE | MERCK & CO., INC. (US) | 2008-04-03 | — | — | WO | disclosed |