Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | DCK | P27707 | 1/20 | 0.41 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.40 |
| ▸ | SELE | P16581 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4061973 | 0.82 | KDM4E (0.60) | CYP3A4CYP1A2CYP2C19SLC6A2SLC6A4 | |
| SCHEMBL21572358 | 0.79 | KMT2A (0.48) | CYP3A4CYP1A2CYP2C19SLC6A2SLC6A4 | |
| SCHEMBL21572388 | 0.78 | CYP1A2 (0.50) | CYP1A2CYP2C19L3MBTL1POLBUHRF1 | |
| SCHEMBL30466097 | 0.76 | KDM4E (0.52) | CYP3A4CYP1A2CYP2C19SLC6A2SLC6A4 | |
| SCHEMBL4068452 | 0.76 | CYP3A4 (0.44) | CYP3A4CYP1A2CYP2C19SLC6A2SLC6A4 | |
| SCHEMBL25279294 | 0.76 | KDM4E (0.52) | CYP3A4CYP1A2CYP2C19SLC6A2SLC6A4 | |
| SCHEMBL4062644 | 0.76 | CYP3A4 (0.44) | CYP3A4CYP1A2CYP2C19SLC6A2SLC6A4 | |
| SCHEMBL807773 | 0.74 | SLC6A2 (0.59) | CYP3A4CYP1A2CYP2C19SLC6A2SLC6A4 | |
| SCHEMBL18331405 | 0.74 | MEN1 (0.60) | UHRF1SMN1; SMN2LMNAMEN1KMT2A | |
| SCHEMBL4061661 | 0.74 | CYP1A2 (0.52) | CYP3A4CYP1A2CYP2C19SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1028945-B9 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | AMGEN INC (US) | 2009-02-18 | — | — | EP | disclosed |
| EP-1028945-B1 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | AMGEN INC (US) | 2007-07-11 | — | — | EP | disclosed |
| EP-1028945-A1 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | Amgen Inc. (US) | 2000-08-23 | — | — | EP | disclosed |
| WO-1999024404-A1 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | AMGEN INC. (US) | 1999-05-20 | — | — | WO | disclosed |