Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 16/20 | 0.62 |
| ▸ | SYK | P43405 | 6/20 | 0.60 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4057862 | 0.90 | AURKA (0.76) | AURKASYKAURKB | |
| SCHEMBL4055453 | 0.83 | AURKA (0.78) | AURKASYKAURKB | |
| SCHEMBL4060368 | 0.81 | AURKA (0.62) | AURKASYKAURKB | |
| SCHEMBL4060374 | 0.80 | AURKA (0.53) | AURKASYKAURKB | |
| SCHEMBL4058178 | 0.77 | AURKA (1.00) | AURKASYKAURKB | |
| SCHEMBL4060475 | 0.77 | AURKA (1.00) | AURKASYKAURKB | |
| SCHEMBL4057976 | 0.76 | AURKA (1.00) | AURKASYKAURKB | |
| SCHEMBL4057120 | 0.76 | AURKA (1.00) | AURKASYKAURKB | |
| SCHEMBL4063395 | 0.76 | AURKA (1.00) | AURKASYKAURKB | |
| SCHEMBL4058794 | 0.76 | AURKA (0.83) | AURKASYKAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1794148-B1 | NOVEL PHTHALAZINONE DERIVATIVES, AS AURORA-A KINASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2009-04-15 | — | — | EP | disclosed |