Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 14/20 | 0.53 |
| ▸ | SYK | P43405 | 5/20 | 0.52 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4057862 | 0.83 | AURKA (0.76) | AURKASYKAURKB | |
| SCHEMBL4060370 | 0.80 | AURKA (0.62) | AURKASYKAURKB | |
| SCHEMBL4055453 | 0.76 | AURKA (0.78) | AURKASYKAURKB | |
| SCHEMBL4060368 | 0.75 | AURKA (0.62) | AURKASYKAURKB | |
| SCHEMBL4058178 | 0.70 | AURKA (1.00) | AURKASYKAURKB | |
| SCHEMBL4060475 | 0.70 | AURKA (1.00) | AURKASYKAURKB | |
| SCHEMBL17977177 | 0.69 | AURKA (0.57) | AURKASYKAURKBNTRK1 | |
| SCHEMBL4055241 | 0.69 | AURKA (0.70) | AURKASYKAURKB | |
| SCHEMBL4057976 | 0.69 | AURKA (1.00) | AURKASYKAURKB | |
| SCHEMBL4057413 | 0.69 | SYK (0.69) | AURKASYKAURKBNTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1794148-B1 | NOVEL PHTHALAZINONE DERIVATIVES, AS AURORA-A KINASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2009-04-15 | — | — | EP | disclosed |