Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 8/20 | 0.50 |
| ▸ | NPC1 | O15118 | 6/20 | 0.50 |
| ▸ | TP53 | P04637 | 3/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27591767 | 0.88 | RAB9A (0.48) | RAB9ANPC1TP53THRBNOTUM | |
| SCHEMBL1544808 | 0.84 | NOTUM (0.69) | RAB9ANPC1TP53THRBNOTUM | |
| SCHEMBL4060532 | 0.81 | NOTUM (0.70) | RAB9ANPC1TP53NOTUMALDH1A1 | |
| SCHEMBL1844414 | 0.81 | NOTUM (0.53) | RAB9ANPC1TP53THRBNOTUM | |
| SCHEMBL2538472 | 0.81 | NOTUM (0.68) | RAB9ANPC1NOTUMALDH1A1TDP1 | |
| SCHEMBL1545508 | 0.80 | SOS1 (0.58) | RAB9ANPC1TP53THRBALDH1A1 | |
| SCHEMBL2489301 | 0.80 | RAB9A (0.50) | RAB9ANPC1TP53THRBNOTUM | |
| SCHEMBL2537431 | 0.79 | MAPT (0.59) | RAB9ANPC1NOTUMALDH1A1TDP1 | |
| SCHEMBL2904235 | 0.78 | TP53 (0.47) | RAB9ANPC1TP53THRBALDH1A1 | |
| SCHEMBL2896502 | 0.78 | TP53 (0.50) | RAB9ANPC1TP53THRBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1208097-B1 | SUBSTITUTED OXOAZAHETEROCYCLYL COMPOUNDS | AVENTIS PHARMA INC (US) | 2009-02-18 | — | — | EP | disclosed |
| EP-1208097-B1 | SUBSTITUTED OXOAZAHETEROCYCLYL COMPOUNDS | AVENTIS PHARMA INC (US) | 2009-02-18 | — | — | EP | disclosed |
| EP-1208097-A2 | SUBSTITUTED OXOAZAHETEROCYCLYL COMPOUNDS | Aventis Pharmaceuticals Inc. (US) | 2002-05-29 | — | — | EP | disclosed |
| WO-2001007436-A2 | SUBSTITUTED OXOAZAHETEROCYCLYL COMPOUNDS | AVENTIS PHARMACEUTICALS INC. (US) | 2001-02-01 | — | — | WO | disclosed |