Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | CASP6 | P55212 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ITK | Q08881 | 2/20 | 0.37 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.37 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | TACR1 | P25103 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4061859 | 0.82 | MCL1 (0.42) | MCL1KDM4EMEN1ALDH1A1POLB | |
| SCHEMBL5012504 | 0.73 | PPARG (0.54) | PPARGPPARDPPARAPTGDR2 | |
| SCHEMBL28666661 | 0.72 | PTGDR2 (0.53) | PRKD3MAP4K4KDRGSK3AGSK3B | |
| SCHEMBL5617095 | 0.72 | KDM4E (0.40) | MCL1KDM4EMEN1ALDH1A1POLB | |
| SCHEMBL6052560 | 0.71 | PPARD (0.54) | MAPTPPARGPPARDPPARA | |
| SCHEMBL4055211 | 0.71 | NR1H3 (0.65) | PPARGPPARDPPARA | |
| SCHEMBL4063165 | 0.70 | GAA (0.48) | MCL1KDM4EMEN1ALDH1A1POLB | |
| SCHEMBL6052553 | 0.70 | PPARD (0.54) | PPARGPPARDPPARA | |
| SCHEMBL20595203 | 0.70 | CLK4 (0.43) | ALDH1A1ITKADRB2PRKD3MAP4K4 | |
| Trifluoroacetic Acid SCHEMBL20595199 | 0.70 | GSK3A (0.41) | ADRB2PRKD3MAP4K4MARK3KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1689389-A4 | INDOLE COMPOUNDS | NAT HEALTH RESEARCH INSTITUTES (TW) | 2009-06-17 | — | — | EP | disclosed |
| EP-1689389-A2 | INDOLE COMPOUNDS | National Health Research Institutes (TW) | 2006-08-16 | — | — | EP | disclosed |
| WO-2005056522-A2 | INDOLE COMPOUNDS | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2005-06-23 | — | — | WO | disclosed |