Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Asenapine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 8/20 | 1.00 |
| ▸ | HTR2A known ✓ | P28223 | 7/20 | 1.00 |
| ▸ | HTR2C | P28335 | 7/20 | 1.00 |
| ▸ | DRD3 | P35462 | 5/20 | 1.00 |
| ▸ | HRH1 | P35367 | 5/20 | 1.00 |
| ▸ | DRD4 | P21917 | 5/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 4/20 | 1.00 |
| ▸ | ADRA2C | P18825 | 4/20 | 1.00 |
| ▸ | DRD1 | P21728 | 4/20 | 1.00 |
| ▸ | CHRM2 | P08172 | 2/20 | 1.00 |
| ▸ | HTR1A | P08908 | 2/20 | 1.00 |
| ▸ | ADRA2B | P18089 | 2/20 | 1.00 |
| ▸ | SLC6A2 | P23975 | 2/20 | 1.00 |
| ▸ | SLC6A4 | P31645 | 2/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 2/20 | 1.00 |
| ▸ | HTR2B | P41595 | 2/20 | 1.00 |
| ▸ | HTR3A | P46098 | 2/20 | 1.00 |
| ▸ | HTR6 | P50406 | 2/20 | 1.00 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 2/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Asenapine SCHEMBL30544842 | 1.00 | DRD2 (1.00) | DRD2HTR2AHTR2CDRD3HRH1 | |
| Asenapine SCHEMBL30413463 | 1.00 | DRD2 (1.00) | DRD2HTR2AHTR2CDRD3HRH1 | |
| Asenapine SCHEMBL29608307 | 1.00 | DRD2 (1.00) | DRD2HTR2AHTR2CDRD3HRH1 | |
| Asenapine SCHEMBL2221502 | 1.00 | DRD2 (1.00) | DRD2HTR2AHTR2CDRD3HRH1 | |
| Asenapine SCHEMBL3805507 | 1.00 | DRD2 (1.00) | DRD2HTR2AHTR2CDRD3HRH1 | |
| Asenapine SCHEMBL30876933 | 1.00 | DRD2 (1.00) | DRD2HTR2AHTR2CDRD3HRH1 | |
| Asenapine SCHEMBL11537117 | 1.00 | DRD2 (1.00) | DRD2HTR2AHTR2CDRD3HRH1 | |
| Asenapine SCHEMBL114123 | 1.00 | DRD2 (1.00) | DRD2HTR2AHTR2CDRD3HRH1 | |
| Asenapine SCHEMBL8008417 | 1.00 | DRD2 (1.00) | DRD2HTR2AHTR2CDRD3HRH1 | |
| Asenapine SCHEMBL29365680 | 1.00 | DRD2 (1.00) | DRD2HTR2AHTR2CDRD3HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2078024-A1 | AMORPHOUS ASENAPINE AND PROCESSES FOR PREPARING SAME | N.V. Organon (NL) | 2009-07-15 | — | — | EP | claimed |
| WO-2008040816-A1 | AMORPHOUS ASENAPINE AND PROCESSES FOR PREPARING SAME | N.V. ORGANON (NL) | 2008-04-10 | — | — | WO | claimed |
| WO-2023097204-A1 | MICROSPHERE FORMULATIONS COMPRISING ASENAPINE AND METHODS FOR MAKING AND USING THE SAME | OAKWOOD LABORATORIES, LLC (US) | 2023-06-01 | — | — | WO | disclosed |
| EP-2705041-B1 | CRYSTALLINE SALTS OF ASENAPINE | OLON SPA (IT) | 2017-10-25 | — | — | EP | disclosed |
| EP-2521711-B1 | QUATERNARY AMMONIUM SALT PRODRUGS | ALKERMES PHARMA IRELAND LTD (IE) | 2017-08-16 | — | — | EP | disclosed |
| EP-2758030-A1 | COMPRESSED ORAL DOSAGE FORM FOR ASENAPINE MALEATE | Hexal AG (DE) | 2014-07-30 | — | — | EP | disclosed |
| WO-2013041435-A1 | COMPRESSED ORAL DOSAGE FORM FOR ASENAPINE MALEATE | HEXAL AG (DE) | 2013-03-28 | — | — | WO | disclosed |
| WO-2012150538-A1 | CRYSTALLINE SALTS OF ASENAPINE | OLON SPA (IT) | 2012-11-08 | — | — | WO | disclosed |
| WO-2011084846-A1 | QUATERNARY AMMONIUM SALT PRODRUGS | ALKERMES, INC. (US) | 2011-07-14 | — | — | WO | disclosed |
| EP-2078024-A1 | AMORPHOUS ASENAPINE AND PROCESSES FOR PREPARING SAME | N.V. Organon (NL) | 2009-07-15 | — | — | EP | disclosed |
| EP-1917267-B1 | CRYSTAL FORM OF ASENAPINE MALEATE | ORGANON NV (NL) | 2008-12-24 | — | — | EP | disclosed |
| WO-2008040816-A1 | AMORPHOUS ASENAPINE AND PROCESSES FOR PREPARING SAME | N.V. ORGANON (NL) | 2008-04-10 | — | — | WO | disclosed |
| EP-1710245-B1 | Crystal form of asenapine maleate | ORGANON NV (NL) | 2007-08-22 | — | — | EP | disclosed |
| EP-1710245-A1 | Crystal form of asenapine maleate | Organon Ireland Ltd. (IE) | 2006-10-11 | — | — | EP | disclosed |