Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 2/20 | 0.47 |
| ▸ | GRM8 | O00222 | 1/20 | 0.47 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 2/20 | 0.39 |
| ▸ | HTR2B | P41595 | 2/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4065167 | 0.82 | SLC6A2 (0.49) | GRM4GRM8GRM7CYP1A2CYP3A4 | |
| SCHEMBL4061697 | 0.81 | GRM8 (0.55) | GRM4GRM8GRM7HTR2CHTR2B | |
| SCHEMBL4065181 | 0.78 | GRM4 (0.57) | GRM4GRM8GRM7KMT2AMEN1 | |
| SCHEMBL4058614 | 0.77 | GRM8 (0.53) | GRM4GRM8GRM7HTR2CHTR2B | |
| SCHEMBL4060811 | 0.74 | GRM8 (0.56) | GRM4GRM8GRM7KMT2AMEN1 | |
| SCHEMBL17244759 | 0.74 | GRM8 (0.51) | GRM4GRM8GRM7HTR2CHTR2B | |
| SCHEMBL4062244 | 0.74 | PNLIP (0.60) | GRM4GRM8GRM7CYP2C19KMT2A | |
| SCHEMBL4061973 | 0.73 | KDM4E (0.60) | CYP1A2CYP3A4CYP2C19SLC6A2SLC6A4 | |
| SCHEMBL4064115 | 0.73 | GRM8 (0.52) | GRM4GRM8GRM7KMT2AMEN1 | |
| SCHEMBL4066243 | 0.72 | CYP1A2 (0.40) | GRM4GRM8GRM7CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1028945-B9 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | AMGEN INC (US) | 2009-02-18 | — | — | EP | claimed |
| EP-1028945-B1 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | AMGEN INC (US) | 2007-07-11 | — | — | EP | claimed |