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Sugi Predict / Targets / PNLIP

PNLIP

Pancreatic triacylglycerol lipase · P16233 · PNLIP on Sugi Atlas →

11,888 patent compounds predicted against PNLIP, 8,127 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL2171478 SCHEMBL2171478 0.63 15/20
SCHEMBL1005838 SCHEMBL1005838 0.56 15/20
Rafoxanide Rafoxanide (SCHEMBL118031) 1.00 14/20
SCHEMBL1372913 SCHEMBL1372913 0.57 13/20
SCHEMBL1372917 SCHEMBL1372917 0.57 13/20
SCHEMBL1284188 SCHEMBL1284188 0.47 10/20
SCHEMBL2171467 SCHEMBL2171467 0.45 9/20
SCHEMBL2170621 SCHEMBL2170621 0.62 8/20
SCHEMBL2303571 SCHEMBL2303571 0.53 8/20
Salicylanilide Salicylanilide (SCHEMBL1877537) 0.48 7/20
SCHEMBL1375560 SCHEMBL1375560 0.46 7/20
SCHEMBL1375562 SCHEMBL1375562 0.46 7/20
SCHEMBL2274195 SCHEMBL2274195 0.66 6/20
SCHEMBL1514346 SCHEMBL1514346 0.49 6/20
SCHEMBL2171471 SCHEMBL2171471 0.45 6/20
SCHEMBL2196772 SCHEMBL2196772 0.66 5/20
SCHEMBL675767 SCHEMBL675767 0.62 5/20
SCHEMBL330458 SCHEMBL330458 0.51 5/20
SCHEMBL2438158 SCHEMBL2438158 0.49 5/20
SCHEMBL1569811 SCHEMBL1569811 0.47 5/20

Clinical trials — most relevant to PNLIP by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
The Effect of Clevidipine on Intracranial Pressure and Cerebral Perfusion Pressure (CCP) in Brain Injured Patients PHASE4WITHDRAWN
Pancreatic Enzyme Replacement in Acute Necrotizing Pancreatitis PHASE3RECRUITING
PERT in Acute Necrotizing Pancreatitis PHASE3NOT_YET_RECRUITING
SOLUTION: Study of Oral Liprotamase Unit-Matched Therapy Of Non-Porcine Origin in Patients With Cystic Fibrosis PHASE3COMPLETED
Orlistat for the Treatment of Type I Hyperlipoproteinemia PHASE2COMPLETED
Pancreaze (Pancrelipase) for Patients With Pancreatic Adenocarcinoma With Cachexia and Exocrine Pancreatic Insufficiency PHASE2ACTIVE_NOT_RECRUITING
An Effectiveness, Safety, and Palatability Study of Pancrelipase Microtablets in Infants and Toddlers With Cystic Fibrosis and Fat Malabsorption PHASE2COMPLETED
Study of Gemcabene in Adults With FPLD PHASE1/PHASE2COMPLETED
Acetylcarnitine and Insulin Sensitivity PHASE2COMPLETED
Safety and Tolerability of Intravenous Fish Oil Lipid Emulsion in Children Undergoing Hematopoietic Cell Transplantation PHASE1COMPLETED
Ability of a Tea Leaf Extracts Preparation to Slow Down Carbohydrate and Fat Absorption PHASE1COMPLETED
Human Models of Selective Insulin Resistance: Pancreatic Clamp PHASE1NOT_YET_RECRUITING
Effect of Gemfibrozil on Serum Glycosylphosphatidylinositol (GPI) Phospholipase D and Triglycerides PHASE1COMPLETED
A Study of the Enzyme Activity and Safety of Pancrelipase in Patients With Severe Exocrine Pancreatic Insufficiency (EPI) PHASE1COMPLETED
CS-121 APOC3 Base Editing in FCS EARLY_PHASE1RECRUITING
Acute Pancreatitis Targets (APT) Study nanCOMPLETED
Study Comparing Blood Levels of Fatty Acids After Consuming Two Forms of Cod Liver Oil nanCOMPLETED
Hypertriglyceridemia-associated Acute Pancreatitis: Apheresis Vs. Conservative Treatment nanCOMPLETED
Triglyceride-rich LIPoproteins and INflammatory Cytokines After Oral FAT Loading as Potential Early Biomarkers of the Risk of Progression Towards DIABETES and Development of Complications. LIPINFAT Diabetes Study. nanRECRUITING
The Evaluation of Pro/Antioxidative Profile and Diagnostic Parameters in the Patients With Pancreatic Disease nanCOMPLETED
An Analysis of Lipid and Glucose Metabolism Following Bariatric Surgery nanCOMPLETED
Correlation of Polymorphisms of Lipoprotein Lipase (LpL) and Apolipoprotein E (Apo E) With Lipid Profile of Children With Acute Lymphoblastic Eukaemia During Therapy With L - Asparaginase. nanUNKNOWN
Effect of Molecular Hydrogen in Patients With NAFLD nanCOMPLETED
Study to Re-assess and Re-confirm Data Previously Recorded About the Incidence and Severity of Acute Abdominal Pancreatitis Episodes in Lipoprotein Lipase Deficient (LPLD) Subjects Previously Enrolled on AMT Clinical Studies nanUNKNOWN
A Proof-of-Concept Study Evaluating LINFU™ nanCOMPLETED
Observational Cohort of Pancreatic Echo-endoscopy nanCOMPLETED
Serum Lipase and Severity of Pancreatic Injury. nanCOMPLETED
Laser Lithotripsy for Difficult Large Bile Duct Stones nanUNKNOWN
Effect of Saturated Fat on Large Low-density Lipoprotein (LDL) and High-density Lipoprotein (HDL) nanCOMPLETED
Characterization of Fatty Acid Composition of Triglycerides in Patients With Hypertriglyceridemia-induced Acute Pancreatitis nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a PNLIP binder may also engage these)

ProteinNameSimilarity
P54316 — 1.000 P54316 →
P29183 — 1.000 P29183 →
Q64425 — 0.999 Q64425 →
Q5BKQ4 — 0.999 Q5BKQ4 →
P54315 — 0.999 P54315 →
P54318 — 0.999 P54318 →
Q6P8U6 — 0.999 Q6P8U6 →
O88354 — 0.998 O88354 →
A5PK46 — 0.998 A5PK46 →
P27657 — 0.998 P27657 →
P81139 — 0.998 P81139 →
D7EZN2 — 0.997 D7EZN2 →
Q64424 — 0.997 Q64424 →
P06857 — 0.997 P06857 →
P54317 — 0.997 P54317 →
P00591 — 0.996 P00591 →
Q17RR3 — 0.996 Q17RR3 →
P50903 — 0.994 P50903 →
Q02157 — 0.994 Q02157 →
P17892 — 0.991 P17892 →
Q6Q252 — 0.987 Q6Q252 →
P0DMB5 — 0.985 P0DMB5 →
A2VBC4 — 0.985 A2VBC4 →
Q6Q249 — 0.984 Q6Q249 →
P51528 — 0.984 P51528 →
Q9U6W0 — 0.984 Q9U6W0 →
Q6Q251 — 0.984 Q6Q251 →
A0A0M3KKW3 — 0.984 A0A0M3KKW3 →
Q3ZU95 — 0.984 Q3ZU95 →
P49369 — 0.984 P49369 →