Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 7/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | AMPD2 | Q01433 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4055078 | 0.92 | SLC6A2 (0.35) | KDM4EL3MBTL1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL4061452 | 0.92 | SLC6A2 (0.35) | KDM4EL3MBTL1SLC6A4SLC6A2KMT2A | |
| SCHEMBL4061994 | 0.89 | SLC6A2 (0.43) | SLC6A4SLC6A2SLC6A3KCNH2 | |
| SCHEMBL4055075 | 0.85 | SLC6A2 (0.43) | SLC6A4SLC6A2SLC6A3KCNH2 | |
| SCHEMBL4058532 | 0.84 | SLC6A2 (0.42) | KDM4EL3MBTL1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL4061456 | 0.81 | SLC6A2 (0.41) | SLC6A4SLC6A2SLC6A3KCNH2 | |
| SCHEMBL4053690 | 0.80 | SLC6A2 (0.37) | KDM4EL3MBTL1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL4056101 | 0.80 | SLC6A2 (0.42) | KDM4EL3MBTL1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL4055129 | 0.80 | SLC6A2 (0.52) | SLC6A4SLC6A2SLC6A3KCNH2 | |
| SCHEMBL4062006 | 0.79 | SLC6A2 (0.41) | SLC6A4SLC6A2SLC6A3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2061776-A1 | ARYL SULFAMIDE DERIVATIVES AND METHODS OF THEIR USE | Wyeth a Corporation of the State of Delaware (US) | 2009-05-27 | — | — | EP | disclosed |
| WO-2008073459-A1 | ARYL SULFAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-06-19 | — | — | WO | disclosed |