Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 6/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.37 |
| ▸ | DRD2 | P14416 | 6/20 | 0.35 |
| ▸ | DRD3 | P35462 | 6/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 2/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 2/20 | 0.33 |
| ▸ | HTR2A | P28223 | 2/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4061460 | 0.92 | SLC6A2 (0.38) | SLC6A2SLC6A4SLC6A3DRD2DRD3 | |
| SCHEMBL4940915 | 0.85 | SLC6A2 (0.46) | SLC6A2SLC6A4SLC6A3DRD2DRD3 | |
| SCHEMBL4062295 | 0.83 | SLC6A2 (0.46) | SLC6A2SLC6A4SLC6A3DRD2DRD3 | |
| SCHEMBL4055129 | 0.83 | SLC6A2 (0.52) | SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL4056113 | 0.81 | SLC6A2 (0.42) | SLC6A2SLC6A4SLC6A3DRD2DRD3 | |
| SCHEMBL4062000 | 0.79 | KDM4E (0.38) | SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL4053695 | 0.79 | RAB9A (0.40) | SLC6A2SLC6A4SLC6A3DRD2DRD3 | |
| SCHEMBL4943820 | 0.79 | SLC6A2 (0.37) | SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL4943708 | 0.78 | SLC6A2 (0.43) | SLC6A2SLC6A4SLC6A3DRD2DRD3 | |
| SCHEMBL4053143 | 0.77 | SLC6A2 (0.42) | SLC6A2SLC6A4SLC6A3DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2061776-A1 | ARYL SULFAMIDE DERIVATIVES AND METHODS OF THEIR USE | Wyeth a Corporation of the State of Delaware (US) | 2009-05-27 | — | — | EP | disclosed |
| WO-2008073459-A1 | ARYL SULFAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-06-19 | — | — | WO | disclosed |