Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | CCR3 | P51677 | 1/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | ABL1 | P00519 | 1/20 | 0.53 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.53 |
| ▸ | ACHE | P22303 | 2/20 | 0.53 |
| ▸ | DRD2 | P14416 | 1/20 | 0.52 |
| ▸ | DRD4 | P21917 | 1/20 | 0.52 |
| ▸ | DRD3 | P35462 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | MC4R | P32245 | 1/20 | 0.51 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3709310 | 0.87 | RECQL (0.70) | RECQLSMN1; SMN2TSHRCCR3ACHE | |
| SCHEMBL13632432 | 0.87 | CCR3 (0.69) | CCR3MC4RSIGMAR1 | |
| SCHEMBL6740759 | 0.87 | CCR3 (0.69) | CCR3MC4RSIGMAR1 | |
| SCHEMBL19170201 | 0.87 | CCR3 (0.69) | CCR3MC4RSIGMAR1 | |
| SCHEMBL3961457 | 0.85 | SMN1; SMN2 (0.66) | RECQLSMN1; SMN2TSHRACHEDRD2 | |
| SCHEMBL5378782 | 0.85 | RECQL (0.56) | RECQLSMN1; SMN2TSHRCCR3ACHE | |
| Hydrochloric Acid SCHEMBL3706762 | 0.85 | RECQL (0.68) | RECQLSMN1; SMN2TSHRCCR3ACHE | |
| SCHEMBL3956954 | 0.84 | MC4R (0.69) | RECQLSMN1; SMN2TSHRCCR3ACHE | |
| SCHEMBL13432148 | 0.84 | MC4R (0.69) | RECQLSMN1; SMN2TSHRACHEDRD2 | |
| SCHEMBL1244038 | 0.82 | CCR3 (0.72) | CCR3KCNH2MC4RSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2109605-A2 | 2- [(PHENYLAMINO) -PYRIMIDIN-4YLAMIN0] -CYCLOPENTANE CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS INHIBITORS OF KINASES OF THE CELL CYCLE FOR THE TREATMENT OF CANCER | Boehringer Ingelheim International GmbH (DE) | 2009-10-21 | — | — | EP | disclosed |
| WO-2008077885-A2 | 2- [(PHENYLAMINO) -PYRIMIDIN-4YLAMIN0] -CYCLOPENTANE CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS INHIBITORS OF KINASES OF THE CELL CYCLE FOR THE TREATMENT OF CANCER | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-07-03 | — | — | WO | disclosed |