Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 17/20 | 0.77 |
| ▸ | KIF23 | Q02241 | 1/20 | 0.77 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | PDE6D | O43924 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3891350 | 0.94 | KIF11 (0.68) | KIF11KIF23MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL4070900 | 0.91 | KIF11 (0.65) | KIF11KIF23MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL3863626 | 0.88 | KIF11 (0.91) | KIF11KIF23MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL3863629 | 0.88 | KIF11 (0.91) | KIF11KIF23MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL3870011 | 0.88 | KIF11 (0.91) | KIF11KIF23MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL4065905 | 0.88 | KIF11 (0.81) | KIF11KIF23MAP1LC3BCYP3A4CYP2C19 | |
| Hydrochloric Acid SCHEMBL3875151 | 0.88 | KIF11 (0.89) | KIF11KIF23MAP1LC3BCYP3A4CYP2C19 | |
| Azd-4877 SCHEMBL3867651 | 0.87 | KIF11 (1.00) | KIF11KIF23MAP1LC3BCYP3A4CYP2C19 | |
| Azd-4877 SCHEMBL360704 | 0.87 | KIF11 (1.00) | KIF11KIF23MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL3873749 | 0.87 | KIF11 (0.85) | KIF11KIF23MAP1LC3BCYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1781673-B1 | SELECTED FUSED HETEROCYCLICS AND USES THEREOF | ASTRAZENECA AB (SE) | 2009-10-21 | — | — | EP | disclosed |