Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 20/20 | 0.69 |
| ▸ | HTR2B | P41595 | 9/20 | 0.55 |
| ▸ | HTR2A | P28223 | 5/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | MTOR | P42345 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4061768 | 0.88 | HTR2C (0.62) | HTR2CHTR2BHTR2ANPC1MTOR | |
| SCHEMBL4061677 | 0.88 | HTR2C (0.53) | HTR2CNPC1MTORRAB9A | |
| SCHEMBL4073222 | 0.87 | HTR2C (0.71) | HTR2CHTR2BHTR2ANPC1MTOR | |
| SCHEMBL4060843 | 0.82 | HTR2C (0.50) | HTR2CMTORRAB9A | |
| SCHEMBL4062759 | 0.82 | HTR2C (0.54) | HTR2CNPC1MTORRAB9A | |
| SCHEMBL4236768 | 0.82 | HTR2C (1.00) | HTR2CHTR2B | |
| SCHEMBL4058761 | 0.81 | HTR2C (0.48) | HTR2CMTORRAB9A | |
| SCHEMBL4065333 | 0.81 | HTR2C (0.48) | HTR2CHTR2BNPC1MTORRAB9A | |
| SCHEMBL4058614 | 0.81 | GRM8 (0.53) | HTR2CHTR2BHTR2A | |
| SCHEMBL4229637 | 0.79 | HTR2C (0.67) | HTR2CHTR2BHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1028945-B9 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | AMGEN INC (US) | 2009-02-18 | — | — | EP | disclosed |
| EP-1028945-B1 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | AMGEN INC (US) | 2007-07-11 | — | — | EP | disclosed |