Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 19/20 | 0.71 |
| ▸ | HTR2B | P41595 | 8/20 | 0.57 |
| ▸ | HTR2A | P28223 | 4/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | MTOR | P42345 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4058778 | 0.89 | GAA (0.56) | HTR2CNPC1RAB9AGAAHTT | |
| SCHEMBL4063908 | 0.87 | HTR2C (0.69) | HTR2CHTR2BHTR2ANPC1MTOR | |
| SCHEMBL4236768 | 0.83 | HTR2C (1.00) | HTR2CHTR2B | |
| SCHEMBL8143964 | 0.83 | PKM (0.65) | HTR2CNPC1RAB9AGAAHTT | |
| SCHEMBL4063740 | 0.83 | HTR2C (0.54) | HTR2CNPC1RAB9AGAAHTT | |
| SCHEMBL4069475 | 0.83 | HTR2C (0.51) | HTR2CNPC1RAB9AGAAHTT | |
| SCHEMBL4061474 | 0.83 | HTR2C (0.58) | HTR2CNPC1RAB9AGAAHTT | |
| SCHEMBL4230099 | 0.82 | HTR2C (1.00) | HTR2CHTR2BNPC1RAB9AHTT | |
| SCHEMBL4243281 | 0.82 | HTR2C (1.00) | HTR2CHTR2BNPC1RAB9A | |
| SCHEMBL4241707 | 0.82 | HTR2C (1.00) | HTR2CHTR2BNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1028945-B9 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | AMGEN INC (US) | 2009-02-18 | — | — | EP | disclosed |
| EP-1028945-B1 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | AMGEN INC (US) | 2007-07-11 | — | — | EP | disclosed |