Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.48 |
| ▸ | GAA | P10253 | 6/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | APP | P05067 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | SNCA | P37840 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3147293 | 0.86 | MAPT (0.50) | MAPTGAAALDH1A1KDM4EMEN1 | |
| SCHEMBL29414658 | 0.79 | MAPT (0.56) | MAPTGAAALDH1A1KDM4EMEN1 | |
| SCHEMBL3607119 | 0.79 | MAPT (0.56) | MAPTGAAALDH1A1KDM4EMEN1 | |
| SCHEMBL2677107 | 0.78 | MAPT (0.71) | MAPTGAAALDH1A1KDM4EMEN1 | |
| SCHEMBL4058240 | 0.76 | MAPT (0.47) | MAPTGAAALDH1A1KDM4EMEN1 | |
| SCHEMBL3606443 | 0.76 | ALDH1A1 (0.47) | MAPTGAAALDH1A1KDM4EMEN1 | |
| SCHEMBL29581577 | 0.76 | ALDH1A1 (0.47) | MAPTGAAALDH1A1KDM4EMEN1 | |
| SCHEMBL2601575 | 0.74 | HSD17B10 (0.46) | MAPTGAAALDH1A1KDM4EMEN1 | |
| SCHEMBL3610761 | 0.73 | MAPT (0.56) | MAPTGAAALDH1A1KDM4EMEN1 | |
| SCHEMBL2506416 | 0.73 | GAA (0.45) | MAPTGAAALDH1A1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2061776-A1 | ARYL SULFAMIDE DERIVATIVES AND METHODS OF THEIR USE | Wyeth a Corporation of the State of Delaware (US) | 2009-05-27 | — | — | EP | disclosed |
| WO-2008073459-A1 | ARYL SULFAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-06-19 | — | — | WO | disclosed |