Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 2/20 | 0.55 |
| ▸ | FLT3 | P36888 | 10/20 | 0.53 |
| ▸ | KDR | P35968 | 6/20 | 0.53 |
| ▸ | FLT4 | P35916 | 4/20 | 0.53 |
| ▸ | KIT | P10721 | 2/20 | 0.53 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.51 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | MET | P08581 | 1/20 | 0.51 |
| ▸ | AURKC | Q9UQB9 | 1/20 | 0.51 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | RET | P07949 | 1/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.47 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 2/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3953189 | 0.82 | KDR (0.69) | ALKFLT3KDRFLT4KIT | |
| SCHEMBL3486770 | 0.81 | RET (0.55) | ALKFLT3KDRFLT4KIT | |
| SCHEMBL4049914 | 0.81 | KDR (0.71) | ALKFLT3KDRFLT4KIT | |
| SCHEMBL6329001 | 0.79 | ALK (0.52) | ALKFLT3KDRFLT4KIT | |
| SCHEMBL3486324 | 0.79 | RET (0.57) | ALKFLT3KDRFLT4KIT | |
| SCHEMBL4566082 | 0.78 | ALK (0.66) | ALKFLT3KDRFLT4KIT | |
| SCHEMBL2112477 | 0.77 | ALK (0.59) | ALKFLT3KDRFLT4KIT | |
| SCHEMBL3267645 | 0.76 | ALK (0.73) | ALKFLT3KDRFLT4KIT | |
| SCHEMBL6324208 | 0.75 | FLT3 (0.60) | ALKFLT3KDRFLT4KIT | |
| SCHEMBL6324202 | 0.75 | FLT3 (0.60) | ALKFLT3KDRFLT4KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009030270-A1 | DIHYDROINDOLE DERIVATIVES USEFUL IN PARKINSON'S DISEASE | NOVARTIS AG (CH) | 2009-03-12 | — | — | WO | disclosed |