Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP14 | P54578 | 1/20 | 0.47 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.45 |
| ▸ | FEN1 | P39748 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4062698 | 0.83 | PTGDR2 (0.50) | USP14PTGDR2FEN1MEN1POLB | |
| SCHEMBL15176400 | 0.74 | PTGDR2 (0.40) | PTGDR2KDM4EL3MBTL1DHODHKDM4C | |
| SCHEMBL1150402 | 0.74 | FEN1 (0.52) | FEN1ALDH1A1TSHRCYP2C19KDM4E | |
| SCHEMBL16344498 | 0.73 | PDE4B (0.44) | USP14ALDH1A1GAATSHRPDE4B | |
| SCHEMBL4064009 | 0.72 | EGFR (0.46) | PTGDR2FEN1ALDH1A1KDM4EMAPT | |
| SCHEMBL18378565 | 0.70 | PTGDR2 (0.46) | PTGDR2ALDH1A1GAAKDM4EMAPT | |
| SCHEMBL16344949 | 0.70 | PTGDR2 (0.46) | PTGDR2ALDH1A1KDM4EMAPTATM | |
| SCHEMBL21314031 | 0.70 | PTGDR2 (0.45) | PTGDR2ALDH1A1KDM4EMAPTATM | |
| SCHEMBL16344944 | 0.70 | PTGDR2 (0.57) | PTGDR2ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL16344674 | 0.70 | PTGDR2 (0.45) | PTGDR2ALDH1A1KDM4EMAPTATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1641791-B1 | 3-(GUANIDINOCARBONYL)HETEROCYCLE DERIVATIVES, PREPARATION PROCESS AND INTERMEDIATES OF THIS PROCESS, THEIR USE AS MEDICAMENTS, AND PHARMACEUTICAL COMPOSITIONS INCLUDING THEM | SANOFI AVENTIS DEUTSCHLAND (DE) | 2009-07-29 | — | — | EP | disclosed |