Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | RORC | P51449 | 1/20 | 0.40 |
| ▸ | STS | P08842 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4063277 | 0.92 | GPR119 (0.48) | GPR119KDM4EPKMMAPTSMN1; SMN2 | |
| SCHEMBL4064088 | 0.91 | GPR119 (0.47) | GPR119KDM4EPKMMAPTSMN1; SMN2 | |
| SCHEMBL4059662 | 0.88 | GPR119 (0.53) | GPR119KDM4EPKMSMN1; SMN2TGFBR1 | |
| SCHEMBL4063283 | 0.85 | GPR119 (0.48) | GPR119KDM4EPKMMAPTSMN1; SMN2 | |
| SCHEMBL4054208 | 0.84 | GPR119 (0.41) | GPR119TP53THRB | |
| SCHEMBL4055719 | 0.81 | SLC6A2 (0.49) | GPR119KDM4EPKMMAPTSMN1; SMN2 | |
| SCHEMBL4059665 | 0.80 | GPR119 (0.53) | GPR119KDM4EPKMSMN1; SMN2TGFBR1 | |
| SCHEMBL4062683 | 0.79 | GPR119 (0.55) | GPR119KDM4EPKM | |
| SCHEMBL4063156 | 0.78 | GPR119 (0.51) | GPR119KDM4EPKM | |
| SCHEMBL3600866 | 0.77 | SLC6A2 (0.48) | GPR119KDM4EPKMMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2061776-A1 | ARYL SULFAMIDE DERIVATIVES AND METHODS OF THEIR USE | Wyeth a Corporation of the State of Delaware (US) | 2009-05-27 | — | — | EP | disclosed |
| WO-2008073459-A1 | ARYL SULFAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-06-19 | — | — | WO | disclosed |