Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4072652 | 0.90 | NPC1 (0.60) | NPC1LMNAALDH1A1RAB9AHPGD | |
| SCHEMBL9227838 | 0.88 | NPC1 (0.58) | NPC1LMNAALDH1A1RAB9AHPGD | |
| SCHEMBL4248164 | 0.85 | NPC1 (0.61) | NPC1LMNAALDH1A1RAB9AHPGD | |
| SCHEMBL31352277 | 0.84 | NPC1 (0.62) | NPC1LMNAALDH1A1RAB9AHPGD | |
| SCHEMBL1137591 | 0.82 | NPC1 (0.60) | NPC1LMNAALDH1A1RAB9AHPGD | |
| SCHEMBL173434 | 0.81 | NPC1 (0.68) | NPC1LMNAALDH1A1RAB9AHPGD | |
| SCHEMBL25933933 | 0.80 | NPC1 (0.55) | NPC1LMNAALDH1A1RAB9AHPGD | |
| SCHEMBL4070954 | 0.79 | HPGD (0.60) | NPC1LMNAALDH1A1RAB9AHPGD | |
| SCHEMBL24452557 | 0.78 | NPC1 (0.65) | NPC1LMNAALDH1A1RAB9AHPGD | |
| SCHEMBL5399382 | 0.77 | ADA (0.33) | TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2033955-A1 | Urea derivatives of 1H-pyrazol-4-carboxylic acid with neutrophil chemotaxis inhibiting activity | Universita' Degli Studi Di Genova (IT) | 2009-03-11 | — | — | EP | disclosed |