Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 6/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.34 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.34 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | GPR68 | Q15743 | 1/20 | 0.32 |
| ▸ | BRAF | P15056 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.30 |
| ▸ | RAF1 | P04049 | 1/20 | 0.30 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4066418 | 0.91 | BRAF (0.43) | MAPK14KMT2ATGFBR1RIPK2ACVR1B | |
| SCHEMBL4064671 | 0.79 | PRKCQ (0.45) | MAPK14MAPK9 | |
| SCHEMBL3992567 | 0.76 | MAPK14 (0.45) | MAPK14KMT2ATGFBR1RIPK2ACVR1B | |
| SCHEMBL4064676 | 0.76 | MAPK14 (0.40) | MAPK14KMT2ATGFBR1RIPK2ACVR1B | |
| SCHEMBL4122831 | 0.72 | MAPT (0.43) | MAPK14KMT2ATGFBR1MTORKDM4E | |
| SCHEMBL4066421 | 0.70 | MAPK14 (0.44) | MAPK14BRAFMAPK13MAPK12MAPK11 | |
| SCHEMBL4067901 | 0.67 | BRAF (0.38) | MAPK14KMT2ABRAFMEN1MAPK13 | |
| SCHEMBL4066423 | 0.67 | BRAF (0.43) | MAPK14KMT2ATGFBR1RIPK2ACVR1B | |
| SCHEMBL3992075 | 0.67 | MAPK14 (0.51) | MAPK14KMT2ATGFBR1RIPK2ACVR1B | |
| SCHEMBL11171288 | 0.66 | BRAF (0.60) | MAPK14KMT2AKDM4EHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1713805-B1 | KINASE INHIBITORS | LILLY CO ELI (US) | 2009-06-10 | — | — | EP | disclosed |