Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCQ | Q04759 | 16/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.40 |
| ▸ | CDK1 | P06493 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | PIM1 | P11309 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CDK2 | P24941 | 2/20 | 0.40 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.40 |
| ▸ | CLK2 | P49760 | 2/20 | 0.40 |
| ▸ | GSK3A | P49840 | 2/20 | 0.40 |
| ▸ | GSK3B | P49841 | 2/20 | 0.40 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.40 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.40 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.40 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.40 |
| ▸ | STK3 | Q13188 | 2/20 | 0.40 |
| ▸ | CAMK2B | Q13554 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4066421 | 0.91 | MAPK14 (0.44) | PRKCQMAPK14 | |
| SCHEMBL3992567 | 0.87 | MAPK14 (0.45) | MAPK14 | |
| SCHEMBL4122831 | 0.82 | MAPT (0.43) | MAPK14 | |
| SCHEMBL4067941 | 0.81 | PRKCQ (0.44) | PRKCQMAPK14MAP4K4CDK1CYP3A4 | |
| SCHEMBL4063490 | 0.81 | PRKCQ (0.44) | PRKCQMAPK14 | |
| SCHEMBL4064669 | 0.79 | MAPK14 (0.40) | MAPK14MAPK9 | |
| SCHEMBL4067901 | 0.78 | BRAF (0.38) | PRKCQMAPK14CSNK1DRPS6KA3MAPK9 | |
| SCHEMBL3992075 | 0.77 | MAPK14 (0.51) | MAPK14CYP3A4 | |
| SCHEMBL4060662 | 0.76 | PRKCQ (0.43) | PRKCQMAPK14MAP4K4CDK1CYP3A4 | |
| SCHEMBL4067857 | 0.75 | MAPK14 (0.45) | PRKCQMAPK14CYP3A4CSNK1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1713805-B1 | KINASE INHIBITORS | LILLY CO ELI (US) | 2009-06-10 | — | — | EP | disclosed |