Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 8/20 | 0.51 |
| ▸ | PPARG | P37231 | 8/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | CASP6 | P55212 | 1/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | PPARD | Q03181 | 5/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4055592 | 0.86 | PPARA (0.54) | PPARAPPARGMAPTL3MBTL1MEN1 | |
| SCHEMBL4059391 | 0.85 | PPARG (0.58) | PPARAPPARGMAPTL3MBTL1MEN1 | |
| SCHEMBL4063133 | 0.81 | TSHR (0.51) | PPARAPPARGKDM4EALDH1A1PPARD | |
| SCHEMBL4054495 | 0.81 | TSHR (0.60) | PPARAPPARGKDM4EALDH1A1PPARD | |
| SCHEMBL4062336 | 0.76 | MAPT (0.44) | PPARAPPARGMAPTL3MBTL1MEN1 | |
| SCHEMBL5176537 | 0.74 | KDM4E (0.42) | PPARAPPARGMAPTL3MBTL1MEN1 | |
| SCHEMBL4056810 | 0.74 | PPARG (0.59) | PPARAPPARGPPARDTSHR | |
| SCHEMBL4055198 | 0.74 | PPARG (0.59) | PPARAPPARGMAPTKDM4ETDP1 | |
| SCHEMBL14366327 | 0.74 | GAA (0.63) | PPARAPPARGMAPTL3MBTL1GAA | |
| SCHEMBL7566062 | 0.73 | PPARA (0.69) | PPARAPPARGGAAKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1689389-A4 | INDOLE COMPOUNDS | NAT HEALTH RESEARCH INSTITUTES (TW) | 2009-06-17 | — | — | EP | disclosed |
| EP-1689389-A2 | INDOLE COMPOUNDS | National Health Research Institutes (TW) | 2006-08-16 | — | — | EP | disclosed |
| WO-2005056522-A2 | INDOLE COMPOUNDS | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2005-06-23 | — | — | WO | disclosed |