Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | PPARG | P37231 | 6/20 | 0.49 |
| ▸ | PPARA | Q07869 | 6/20 | 0.49 |
| ▸ | PPARD | Q03181 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4054495 | 0.91 | TSHR (0.60) | TSHRPPARGPPARAPPARDKDM4E | |
| SCHEMBL4056810 | 0.87 | PPARG (0.59) | TSHRPPARGPPARAPPARD | |
| SCHEMBL8180904 | 0.81 | KDM4E (0.56) | TSHRPPARGPPARAPPARDKDM4E | |
| SCHEMBL4064985 | 0.81 | PPARA (0.51) | TSHRPPARGPPARAPPARDKDM4E | |
| SCHEMBL4055198 | 0.79 | PPARG (0.59) | TSHRPPARGPPARAPPARDKDM4E | |
| SCHEMBL29651210 | 0.77 | TSHR (0.77) | TSHRKDM4EALDH1A1LMNAGLA | |
| SCHEMBL4098433 | 0.77 | TSHR (0.77) | TSHRKDM4EALDH1A1LMNAGLA | |
| SCHEMBL8581146 | 0.73 | KDM4E (0.79) | TSHRKDM4EMTNR1AMTNR1BALDH1A1 | |
| SCHEMBL30048580 | 0.73 | KDM4E (0.79) | TSHRKDM4EMTNR1AMTNR1BALDH1A1 | |
| SCHEMBL4473938 | 0.73 | ALDH1A1 (0.65) | PPARGPPARAPPARDKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1689389-A4 | INDOLE COMPOUNDS | NAT HEALTH RESEARCH INSTITUTES (TW) | 2009-06-17 | — | — | EP | disclosed |
| EP-1689389-A2 | INDOLE COMPOUNDS | National Health Research Institutes (TW) | 2006-08-16 | — | — | EP | disclosed |
| WO-2005056522-A2 | INDOLE COMPOUNDS | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2005-06-23 | — | — | WO | disclosed |