Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 16/20 | 0.55 |
| ▸ | CCND1 | P24385 | 14/20 | 0.55 |
| ▸ | CDK2 | P24941 | 8/20 | 0.55 |
| ▸ | FGFR1 | P11362 | 7/20 | 0.55 |
| ▸ | FGFR2 | P21802 | 7/20 | 0.55 |
| ▸ | FGFR4 | P22455 | 7/20 | 0.55 |
| ▸ | FGFR3 | P22607 | 7/20 | 0.55 |
| ▸ | CCNA2 | P20248 | 6/20 | 0.55 |
| ▸ | CCND2 | P30279 | 6/20 | 0.55 |
| ▸ | CCND3 | P30281 | 6/20 | 0.55 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.55 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.54 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.53 |
| ▸ | CDK1 | P06493 | 3/20 | 0.53 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.53 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.53 |
| ▸ | IGF1R | P08069 | 1/20 | 0.53 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.53 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.53 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4068670 | 0.89 | IGF1R (0.57) | CDK4CCND1CDK2CCNA2CCND2 | |
| SCHEMBL4068561 | 0.88 | CDK4 (0.59) | CDK4CCND1CDK2FGFR1FGFR2 | |
| SCHEMBL4067264 | 0.80 | CCND3 (0.59) | CDK4CCND1CDK2CCNA2CCND2 | |
| SCHEMBL4073131 | 0.78 | IGF1R (0.54) | CDK4CCND1CCND2CCND3TNK2 | |
| Tert-Butyl Formate SCHEMBL27821262 | 0.78 | CDK4 (0.46) | CDK4CCND1CDK2FGFR1FGFR2 | |
| SCHEMBL13812805 | 0.77 | CDK4 (0.52) | CDK4CCND1CDK2CCNA2CCND2 | |
| SCHEMBL28775720 | 0.76 | JAK3 (0.57) | CDK4CCND1CDK2CCNA2CCNA1 | |
| SCHEMBL6087900 | 0.73 | CDK4 (0.74) | CDK4CCND1CDK2FGFR1FGFR2 | |
| SCHEMBL28775721 | 0.72 | CA2 (0.53) | CDK4CCND1CDK2CCNE1CDK1 | |
| SCHEMBL13812812 | 0.72 | JAK3 (0.44) | CDK4CCND1CDK2FGFR1FGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8796267-B2 | Oxazolidinone derivatives and methods of use | CONCERT PHARMACEUTICALS, INC. (US) | 2014-08-05 | — | — | US | disclosed |
| EP-1590341-B1 | 2-AMINOPYRIDINE SUBSTITUTED HETEROCYCLES AS INHIBITORS OF CELLULAR PROLIFERATION | WARNER LAMBERT CO (US) | 2009-06-17 | — | — | EP | disclosed |
| EP-1590341-B1 | 2-AMINOPYRIDINE SUBSTITUTED HETEROCYCLES AS INHIBITORS OF CELLULAR PROLIFERATION | WARNER LAMBERT CO (US) | 2009-06-17 | — | — | EP | disclosed |
| EP-1590341-A1 | 2-AMINOPYRIDINE SUBSTITUTED HETEROCYCLES AS INHIBITORS OF CELLULAR PROLIFERATION | WARNER-LAMBERT COMPANY (US) | 2005-11-02 | — | — | EP | disclosed |
| US-20040236084-A1 | E.g., 4-Cyclopentylamino-2-(5-piperazin-1-yl-pyridin-2-ylamino)-pyrimidine-5-carbonitrile; potent inhibitors of cyclin-dependent kinases useful in treating cell proliferative disorders | PFIZER INC | 2004-11-25 | — | — | US | disclosed |
| WO-2004065378-A1 | 2-AMINOPYRIDINE SUBSTITUTED HETEROCYCLES AS INHIBITORS OF CELLULAR PROLIFERATION | WARNER-LAMBERT COMPANY LLC (US) | 2004-08-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040236084-A1 | E.g., 4-Cyclopentylamino-2-(5-piperazin-1-yl-pyridin-2-ylamino)-pyrimidine-5-carbonitrile; potent inhibitors of cyclin-dependent kinases useful in treating cell proliferative disorders | CDK4, CCNA1, CCNI | CDK4 1/4885CCND1 11/4885CDK2 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.