Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 11/20 | 0.49 |
| ▸ | DRD3 | P35462 | 10/20 | 0.49 |
| ▸ | HTR2A | P28223 | 8/20 | 0.49 |
| ▸ | AR | P10275 | 2/20 | 0.49 |
| ▸ | HTR7 | P34969 | 2/20 | 0.48 |
| ▸ | CCR3 | P51677 | 1/20 | 0.47 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3080034 | 0.92 | HTR2A (0.56) | DRD2DRD3HTR2AAR | |
| SCHEMBL4057721 | 0.90 | HTR2A (0.59) | DRD2DRD3HTR2AARCCR3 | |
| SCHEMBL3085008 | 0.90 | HTR2A (0.59) | DRD2DRD3HTR2AARCCR3 | |
| SCHEMBL14715609 | 0.89 | HRH1 (0.45) | DRD2DRD3HTR2ACCR3 | |
| SCHEMBL3067525 | 0.88 | DRD3 (0.53) | DRD2DRD3HTR2ACCR3 | |
| SCHEMBL3078178 | 0.88 | DRD3 (0.53) | DRD2DRD3HTR2ACCR3 | |
| SCHEMBL3091198 | 0.87 | DRD3 (0.47) | DRD2DRD3HTR2ACCR3 | |
| SCHEMBL4076666 | 0.87 | DRD2 (0.56) | DRD2DRD3HTR2AHTR7CCR3 | |
| SCHEMBL3083297 | 0.87 | DRD3 (0.47) | DRD2DRD3HTR2ACCR3 | |
| SCHEMBL3080661 | 0.87 | DRD3 (0.49) | DRD2DRD3HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079693-A1 | ETHER DERIVATIVES DUAL MODULATORS OF THE 5-HT2A AND D3 RECEPTORS | F. Hoffmann-Roche AG (CH) | 2009-07-22 | — | — | EP | claimed |
| WO-2008052899-A1 | ETHER DERIVATIVES DUAL MODULATORS OF THE 5-HT2A AND D3 RECEPTORS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-05-08 | — | — | WO | claimed |
| EP-2079693-B1 | ETHER DERIVATIVES DUAL MODULATORS OF THE 5-HT2A AND D3 RECEPTORS | HOFFMANN LA ROCHE (CH) | 2013-02-27 | — | — | EP | disclosed |
| EP-2079693-A1 | ETHER DERIVATIVES DUAL MODULATORS OF THE 5-HT2A AND D3 RECEPTORS | F. Hoffmann-Roche AG (CH) | 2009-07-22 | — | — | EP | disclosed |
| WO-2008052899-A1 | ETHER DERIVATIVES DUAL MODULATORS OF THE 5-HT2A AND D3 RECEPTORS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-05-08 | — | — | WO | disclosed |