Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 12/20 | 0.57 |
| ▸ | INSR | P06213 | 8/20 | 0.57 |
| ▸ | EGFR | P00533 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | KDR | P35968 | 1/20 | 0.54 |
| ▸ | TNK2 | Q07912 | 8/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.44 |
| ▸ | LYN | P07948 | 1/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.44 |
| ▸ | FLT4 | P35916 | 1/20 | 0.44 |
| ▸ | FLT3 | P36888 | 1/20 | 0.44 |
| ▸ | FRK | P42685 | 1/20 | 0.44 |
| ▸ | STK3 | Q13188 | 1/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.44 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.44 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.44 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL399838 | 0.86 | IGF1R (0.58) | IGF1RINSREGFRCYP3A4KDR | |
| SCHEMBL4067704 | 0.86 | IGF1R (0.62) | IGF1RINSRTNK2 | |
| SCHEMBL399619 | 0.83 | IGF1R (0.74) | IGF1RINSREGFRCYP3A4KDR | |
| SCHEMBL400468 | 0.77 | IGF1R (0.77) | IGF1RINSRTNK2 | |
| SCHEMBL3303492 | 0.75 | IGF1R (0.73) | IGF1RINSREGFRKDRTNK2 | |
| SCHEMBL402493 | 0.75 | IGF1R (0.64) | IGF1RINSREGFRCYP3A4KDR | |
| SCHEMBL4071569 | 0.74 | IGF1R (0.47) | IGF1RINSRTNK2 | |
| SCHEMBL402423 | 0.73 | IGF1R (0.79) | IGF1RINSREGFRCYP3A4KDR | |
| SCHEMBL3294653 | 0.73 | IGF1R (0.76) | IGF1RINSREGFRKDRTNK2 | |
| SCHEMBL401974 | 0.72 | IGF1R (0.59) | IGF1RINSREGFRCYP3A4KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740591-B1 | 6,6-BICYCLIC RING SUBSTITUTED HETEROBICYCLIC PROTEIN KINASE INHIBITORS | OSI PHARM INC (US) | 2009-06-17 | — | — | EP | claimed |