Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 12/20 | 0.62 |
| ▸ | INSR | P06213 | 6/20 | 0.62 |
| ▸ | TNK2 | Q07912 | 8/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4065357 | 0.86 | IGF1R (0.57) | IGF1RINSRTNK2 | |
| SCHEMBL398160 | 0.84 | IGF1R (0.60) | IGF1RINSRTNK2 | |
| SCHEMBL399845 | 0.81 | IGF1R (0.79) | IGF1RINSRTNK2 | |
| SCHEMBL400468 | 0.80 | IGF1R (0.77) | IGF1RINSRTNK2 | |
| SCHEMBL4071569 | 0.79 | IGF1R (0.47) | IGF1RINSRTNK2 | |
| SCHEMBL3453825 | 0.77 | IGF1R (1.00) | IGF1RINSRTNK2 | |
| SCHEMBL3453826 | 0.77 | IGF1R (1.00) | IGF1RINSRTNK2 | |
| SCHEMBL12006593 | 0.75 | IGF1R (0.91) | IGF1RINSRTNK2 | |
| SCHEMBL13626519 | 0.75 | TNK2 (0.79) | IGF1RTNK2 | |
| SCHEMBL402396 | 0.75 | IGF1R (0.75) | IGF1RINSRTNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740591-B1 | 6,6-BICYCLIC RING SUBSTITUTED HETEROBICYCLIC PROTEIN KINASE INHIBITORS | OSI PHARM INC (US) | 2009-06-17 | — | — | EP | claimed |