Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 5/20 | 0.44 |
| ▸ | JAK3 | P52333 | 3/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 10/20 | 0.41 |
| ▸ | AURKA | O14965 | 4/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.41 |
| ▸ | PLK4 | O00444 | 2/20 | 0.41 |
| ▸ | PAK4 | O96013 | 2/20 | 0.41 |
| ▸ | RET | P07949 | 2/20 | 0.41 |
| ▸ | FLT3 | P36888 | 2/20 | 0.41 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.41 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.41 |
| ▸ | STK10 | O94804 | 1/20 | 0.41 |
| ▸ | FER | P16591 | 1/20 | 0.41 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.41 |
| ▸ | STAT3 | P40763 | 1/20 | 0.41 |
| ▸ | STAT5A | P42229 | 1/20 | 0.41 |
| ▸ | CDK3 | Q00526 | 1/20 | 0.41 |
| ▸ | STK4 | Q13043 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL220024 | 0.88 | JAK2 (0.47) | JAK2JAK3NTRK1AURKAFGFR1 | |
| SCHEMBL4073779 | 0.84 | IGF1R (0.42) | JAK2JAK3NTRK1AURKAFGFR1 | |
| SCHEMBL4076750 | 0.82 | IGF1R (0.40) | JAK2JAK3NTRK1AURKAFGFR1 | |
| SCHEMBL217676 | 0.81 | JAK2 (0.42) | JAK2JAK3NTRK1AURKAFGFR1 | |
| SCHEMBL1770945 | 0.76 | FGFR1 (0.46) | JAK2JAK3NTRK1AURKAFGFR1 | |
| SCHEMBL4041620 | 0.76 | NTRK1 (0.46) | JAK2JAK3NTRK1AURKAFGFR1 | |
| SCHEMBL4064988 | 0.76 | JAK2 (0.43) | JAK2JAK3NTRK1AURKAFGFR1 | |
| SCHEMBL217976 | 0.76 | JAK2 (0.39) | JAK2JAK3NTRK1AURKAFGFR1 | |
| SCHEMBL218889 | 0.76 | IGF1R (0.44) | JAK2JAK3NTRK1FGFR1PLK4 | |
| SCHEMBL3338899 | 0.75 | IGF1R (0.42) | JAK2JAK3NTRK1AURKAFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1686999-B1 | PYRAZOLE DERIVATIVES AS INHIBITORS OF RECEPTOR TYROSINE KINASES | ASTRAZENECA AB (SE) | 2009-07-01 | — | — | EP | disclosed |
| CN-1905884-A | Pyrazole derivatives as inhibitors of receptor tyrosyne kinases | ASTRAZENECA AB (SE) | 2007-01-31 | — | — | CN | disclosed |