Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 3/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 3/20 | 0.41 |
| ▸ | JAK3 | P52333 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | PLK4 | O00444 | 2/20 | 0.40 |
| ▸ | PAK4 | O96013 | 2/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 6/20 | 0.39 |
| ▸ | AURKA | O14965 | 2/20 | 0.39 |
| ▸ | STK10 | O94804 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | FER | P16591 | 1/20 | 0.39 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4076750 | 0.90 | IGF1R (0.40) | IGF1RFGFR1KDRJAK2JAK3 | |
| SCHEMBL4076654 | 0.87 | ALDH1A1 (0.43) | IGF1RFGFR1JAK2JAK3MEN1 | |
| SCHEMBL217676 | 0.86 | JAK2 (0.42) | IGF1RFGFR1KDRJAK2JAK3 | |
| SCHEMBL4065430 | 0.84 | JAK2 (0.44) | IGF1RFGFR1KDRJAK2JAK3 | |
| SCHEMBL217976 | 0.84 | JAK2 (0.39) | IGF1RFGFR1KDRJAK2JAK3 | |
| SCHEMBL220024 | 0.83 | JAK2 (0.47) | IGF1RFGFR1KDRJAK2JAK3 | |
| SCHEMBL3338899 | 0.83 | IGF1R (0.42) | IGF1RFGFR1KDRJAK2JAK3 | |
| SCHEMBL4072828 | 0.82 | PLK4 (0.40) | IGF1RFGFR1KDRJAK2JAK3 | |
| SCHEMBL1770945 | 0.81 | FGFR1 (0.46) | IGF1RFGFR1KDRJAK2JAK3 | |
| SCHEMBL218642 | 0.79 | MEN1 (0.62) | IGF1RFGFR1KDRJAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1686999-B1 | PYRAZOLE DERIVATIVES AS INHIBITORS OF RECEPTOR TYROSINE KINASES | ASTRAZENECA AB (SE) | 2009-07-01 | — | — | EP | disclosed |