Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 5/20 | 1.00 |
| ▸ | CLK1 | P49759 | 1/20 | 0.73 |
| ▸ | GSK3B | P49841 | 1/20 | 0.73 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.73 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.73 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.73 |
| ▸ | MAPT | P10636 | 5/20 | 0.64 |
| ▸ | GAA | P10253 | 2/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.64 |
| ▸ | GFER | P55789 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 5/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 3/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4066988 | 0.89 | HTT (1.00) | HTTCLK1GSK3BDYRK1ACLK4 | |
| SCHEMBL4795234 | 0.88 | CLK1 (0.85) | HTTCLK1GSK3BDYRK1ACLK4 | |
| SCHEMBL4071064 | 0.87 | HTT (0.81) | HTTCLK1GSK3BDYRK1ACLK4 | |
| SCHEMBL4063265 | 0.85 | CLK1 (1.00) | HTTCLK1GSK3BDYRK1ACLK4 | |
| SCHEMBL30697294 | 0.85 | CLK1 (1.00) | HTTCLK1GSK3BDYRK1ACLK4 | |
| Acetic Acid SCHEMBL4066978 | 0.83 | CLK1 (0.91) | HTTCLK1GSK3BDYRK1ACLK4 | |
| SCHEMBL14863869 | 0.82 | CLK1 (0.77) | HTTCLK1GSK3BDYRK1ACLK4 | |
| SCHEMBL4062708 | 0.82 | CLK1 (0.93) | HTTCLK1GSK3BDYRK1ACLK4 | |
| SCHEMBL4059111 | 0.80 | HTT (0.67) | HTTCLK1GSK3BDYRK1ACLK4 | |
| SCHEMBL4060302 | 0.80 | HTT (0.67) | HTTCLK1GSK3BDYRK1ACLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8883504-B2 | Cell differentiation suppressing agent, method of culturing cells using the same, culture solution, and cultured cell line | ASAHI KASEI KABUSHIKI KAISHA (JP) | 2014-11-11 | — | — | US | disclosed |
| EP-1960777-B1 | SERUM-FREE EXPANSION OF CELLS IN CULTURE | CHOONGWAE PHARMA CORP (KR) | 2009-10-21 | — | — | EP | disclosed |
| US-20090155906-A1 | CELL DIFFERENTIATION SUPPRESSING AGENT, METHOD OF CULTURING CELLS USING THE SAME, CULTURE SOLUTION, AND CULTURED CELL LINE | MIYABAYASHI TOMOYUKI | 2009-06-18 | — | — | US | disclosed |
| US-20070128669-A1 | Serum-free expansion of cells in culture | INSTITUTE FOR CHEMICAL GENOMICS (US) | 2007-06-07 | — | — | US | disclosed |
| WO-2007025090-A2 | HETEROBICYCLIC AND - TRICYCLIC INHIBITORS OF MAPK/ERK KINASE | KALYPSYS, INC. (US) | 2007-03-01 | — | — | WO | disclosed |
| US-20070049591-A1 | Inhibitors of MAPK/Erk Kinase | KALYPSYS, INC. | 2007-03-01 | — | — | US | disclosed |
| US-20070049591-A1 | Inhibitors of MAPK/Erk Kinase | KALYPSYS, INC. | 2007-03-01 | — | — | US | disclosed |
| US-20070049591-A1 | Inhibitors of MAPK/Erk Kinase | KALYPSYS, INC. | 2007-03-01 | — | — | US | disclosed |
| EP-1640449-A1 | CELL DIFFERENTIATION INHIBITING AGENT, CELL CULTURE METHOD USING THE SAME, CULTURE MEDIUM AND CULTURED CELL LINE | Asahi Kasei Kabushiki Kaisha (JP) | 2006-03-29 | — | — | EP | disclosed |
| US-20050153941-A1 | Increasing Stage Specific Embryonic Antigen (SSEA) and Nanog gene levels; culturing a stem cell using a low molecular weight derivative of 2-(phenylazo)-2-(3,4-dihydro-2H-isoquinoline-1-ylidene) or N-phenylindole | ASAHI KASEI KABUSHIKI KAISHA (JP) | 2005-07-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070049591-A1 | Inhibitors of MAPK/Erk Kinase | MAPK1, MAP3K1, MAP3K6 | HTT 3149/4885CLK1 428/4885GSK3B 489/4885 |
| US-20050153941-A1 | Increasing Stage Specific Embryonic Antigen (SSEA) and Nanog gene levels; culturing a stem cell using a low molecular weight derivative of 2-(phenylazo)-2-(3,4-dihydro-2H-isoquinoline-1-ylidene) or N-phenylindole | MKI67, ALPG, NES | HTT 4510/4885CLK1 4264/4885GSK3B 3504/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.