Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 8/20 | 0.62 |
| ▸ | TNK2 | Q07912 | 12/20 | 0.54 |
| ▸ | INSR | P06213 | 6/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Carbamic Acid SCHEMBL4061882 | 0.94 | IGF1R (0.66) | IGF1RTNK2INSRCYP3A4 | |
| SCHEMBL402396 | 0.91 | IGF1R (0.75) | IGF1RTNK2INSRCYP3A4 | |
| SCHEMBL399474 | 0.90 | IGF1R (0.57) | IGF1RTNK2INSR | |
| SCHEMBL4073360 | 0.88 | IGF1R (0.81) | IGF1RTNK2INSRCYP3A4 | |
| Methylamine SCHEMBL4070820 | 0.88 | IGF1R (0.60) | IGF1RTNK2INSR | |
| SCHEMBL402531 | 0.87 | IGF1R (0.61) | IGF1RTNK2INSR | |
| SCHEMBL4070824 | 0.87 | IGF1R (0.55) | IGF1RTNK2INSR | |
| SCHEMBL398160 | 0.86 | IGF1R (0.60) | IGF1RTNK2INSRCYP3A4 | |
| SCHEMBL399740 | 0.83 | IGF1R (0.62) | IGF1RTNK2INSRCYP3A4 | |
| Carbamic Acid SCHEMBL4070437 | 0.81 | IGF1R (0.86) | IGF1RTNK2INSRCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2168968-B1 | 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitors | OSI PHARMACEUTICALS LLC (US) | 2017-08-23 | — | — | EP | claimed |
| EP-1740591-B1 | 6,6-BICYCLIC RING SUBSTITUTED HETEROBICYCLIC PROTEIN KINASE INHIBITORS | OSI PHARM INC (US) | 2009-06-17 | — | — | EP | claimed |