Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 12/20 | 0.60 |
| ▸ | INSR | P06213 | 6/20 | 0.56 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.51 |
| ▸ | RET | P07949 | 1/20 | 0.51 |
| ▸ | NQO2 | P16083 | 1/20 | 0.51 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.51 |
| ▸ | FECH | P22830 | 1/20 | 0.51 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.51 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.51 |
| ▸ | MTOR | P42345 | 1/20 | 0.51 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.51 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.51 |
| ▸ | PRKDC | P78527 | 1/20 | 0.51 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.51 |
| ▸ | BMPR2 | Q13873 | 1/20 | 0.51 |
| ▸ | RICTOR | Q6R327 | 1/20 | 0.51 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.51 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.51 |
| ▸ | MAPKAP1 | Q9BPZ7 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL402531 | 0.93 | IGF1R (0.61) | IGF1RINSRRIPK2RETNQO2 | |
| SCHEMBL399474 | 0.92 | IGF1R (0.57) | IGF1RINSRRIPK2RETNQO2 | |
| SCHEMBL4070824 | 0.90 | IGF1R (0.55) | IGF1RINSRRIPK2RETNQO2 | |
| Carbamic Acid SCHEMBL4061882 | 0.89 | IGF1R (0.66) | IGF1RINSRTNK2 | |
| SCHEMBL402396 | 0.89 | IGF1R (0.75) | IGF1RINSRTNK2 | |
| SCHEMBL4065701 | 0.88 | IGF1R (0.62) | IGF1RINSRTNK2 | |
| SCHEMBL399740 | 0.86 | IGF1R (0.62) | IGF1RINSRTNK2 | |
| SCHEMBL398160 | 0.85 | IGF1R (0.60) | IGF1RINSRTNK2 | |
| SCHEMBL397534 | 0.80 | IGF1R (0.79) | IGF1RINSRRIPK2RETFECH | |
| SCHEMBL400761 | 0.80 | IGF1R (0.78) | IGF1RINSRRIPK2RETFECH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740591-B1 | 6,6-BICYCLIC RING SUBSTITUTED HETEROBICYCLIC PROTEIN KINASE INHIBITORS | OSI PHARM INC (US) | 2009-06-17 | — | — | EP | claimed |