Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.42 |
| ▸ | LSS | P48449 | 1/20 | 0.40 |
| ▸ | TACR1 | P25103 | 8/20 | 0.40 |
| ▸ | TACR2 | P21452 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.37 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.37 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3050386 | 0.87 | GPBAR1 (0.49) | GPBAR1TACR1TACR2CTSKCES2 | |
| SCHEMBL788092 | 0.84 | TACR1 (0.40) | LSSTACR1SLC6A2SLC6A4 | |
| SCHEMBL30950869 | 0.84 | TACR1 (0.40) | LSSTACR1SLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL787855 | 0.83 | IDO1 (0.42) | LSSTACR1SLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL5913029 | 0.83 | IDO1 (0.42) | LSSTACR1SLC6A2SLC6A4 | |
| SCHEMBL5428175 | 0.76 | TACR1 (0.52) | TACR1SERPINE1 | |
| SCHEMBL346774 | 0.76 | MRGPRX4 (0.48) | LSSTACR1SERPINE1CES2 | |
| SCHEMBL9928607 | 0.76 | RXRA (0.49) | LSSTACR1SERPINE1CES2 | |
| SCHEMBL6121602 | 0.75 | MRGPRX4 (0.47) | LSSTACR1SERPINE1CES2 | |
| Hydrochloric Acid SCHEMBL345549 | 0.75 | MRGPRX4 (0.47) | LSSTACR1SERPINE1CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1511730-B8 | DIARYL UREA DERIVATIVES USEFUL FOR THE TREATMENT OF PROTEIN KINASE DEPENDENT DISEASES | NOVARTIS AG (CH) | 2009-04-08 | — | — | EP | disclosed |
| EP-1511730-A2 | DIARYL UREA DERIVATIVES USEFUL FOR THE TREATMENT OF PROTEIN KINASE DEPENDENT DISEASES | Novartis AG (CH) | 2005-03-09 | — | — | EP | disclosed |
| WO-2003099771-A2 | DIARYL UREA DERIVATIVES USEFUL FOR THE TREATMENT OF PROTEIN KINASE DEPENDENT DISEASES | NOVARTIS AG (CH) | 2003-12-04 | — | — | WO | disclosed |