Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 2/20 | 0.45 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.45 |
| ▸ | GRM5 | P41594 | 2/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 6/20 | 0.37 |
| ▸ | XDH | P47989 | 2/20 | 0.35 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.35 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.35 |
| ▸ | DAO | P14920 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.33 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL989361 | 0.90 | PIK3CA (0.45) | PIK3CAPIK3CBNOTUMXDHSLC22A12 | |
| SCHEMBL1516838 | 0.81 | SRD5A1 (0.38) | GRM5MAOBNOTUMDAOALDH1A1 | |
| SCHEMBL1516816 | 0.80 | PIK3CA (0.39) | PIK3CAPIK3CBGRM5MAOBDAO | |
| SCHEMBL988659 | 0.79 | NOTUM (0.53) | PIK3CAPIK3CBNOTUMDAOALDH1A1 | |
| SCHEMBL4116817 | 0.78 | MAP3K14 (0.48) | PIK3CAPIK3CBGRM5PIK3CDPIK3R1 | |
| SCHEMBL4062281 | 0.76 | PIK3CA (0.48) | PIK3CAPIK3CBMAOBALDH1A1KDM4E | |
| SCHEMBL988949 | 0.75 | PIK3CA (0.63) | PIK3CAPIK3CBNOTUMXDHSLC22A12 | |
| SCHEMBL988982 | 0.73 | NOTUM (0.39) | PIK3CAPIK3CBNOTUMDAOALDH1A1 | |
| SCHEMBL11896939 | 0.72 | ALDH1A1 (0.36) | PIK3CAPIK3CBNOTUMDAOALDH1A1 | |
| SCHEMBL1090921 | 0.71 | GRM5 (0.66) | PIK3CAPIK3CBGRM5MAOBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009123971-A1 | BENZOPYRAN AND BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2009-10-08 | — | — | WO | claimed |
| WO-2009123971-A1 | BENZOPYRAN AND BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2009-10-08 | — | — | WO | disclosed |