Sugi Predict

Sugi Predict / Compounds / Carbamic Acid

Carbamic Acid

Carbamic Acid

SCHEMBL4066334

NC(=O)O.Nc1nccn2c(C3CCCCC3)nc(-c3cc4nc(-c5cccs5)ccc4cc3Cl)c12

nearest known ligand 0.54

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Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ TNK2 Q07912 12/20 0.54
▸ IGF1R P08069 6/20 0.53
▸ CYP3A4 P08684 2/20 0.53
▸ FGFR1 P11362 2/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL399407 0.93 IGF1R (0.59) TNK2IGF1RCYP3A4FGFR1
SCHEMBL399341 0.91 IGF1R (0.62) TNK2IGF1RCYP3A4FGFR1
Carbamic Acid SCHEMBL4072218 0.88 IGF1R (0.66) TNK2IGF1RCYP3A4FGFR1
Carbamic Acid SCHEMBL4069747 0.88 IGF1R (0.69) TNK2IGF1RCYP3A4FGFR1
Carbamic Acid SCHEMBL4074258 0.87 TNK2 (0.61) TNK2IGF1RCYP3A4
SCHEMBL401953 0.87 IGF1R (0.47) TNK2IGF1RCYP3A4FGFR1
SCHEMBL4070080 0.83 IGF1R (0.65) TNK2IGF1RCYP3A4FGFR1
SCHEMBL401729 0.82 IGF1R (0.63) TNK2IGF1RCYP3A4FGFR1
Carbamic Acid SCHEMBL4070573 0.82 TNK2 (0.64) TNK2
Carbamic Acid SCHEMBL4063229 0.82 TNK2 (0.58) TNK2IGF1RCYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2168968-B1 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitors OSI PHARMACEUTICALS LLC (US) 2017-08-23 — — EP claimed
EP-1740591-B1 6,6-BICYCLIC RING SUBSTITUTED HETEROBICYCLIC PROTEIN KINASE INHIBITORS OSI PHARM INC (US) 2009-06-17 — — EP claimed