Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 16/20 | 0.56 |
| ▸ | ROCK1 | Q13464 | 16/20 | 0.56 |
| ▸ | RPS6KA1 | Q15418 | 13/20 | 0.56 |
| ▸ | AKT2 | P31751 | 9/20 | 0.56 |
| ▸ | AKT3 | Q9Y243 | 6/20 | 0.56 |
| ▸ | RPS6KA5 | O75582 | 9/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.51 |
| ▸ | GSK3A | P49840 | 3/20 | 0.51 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.51 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.51 |
| ▸ | PIM1 | P11309 | 2/20 | 0.51 |
| ▸ | PRKACA | P17612 | 2/20 | 0.51 |
| ▸ | MARK3 | P27448 | 2/20 | 0.51 |
| ▸ | CLK2 | P49760 | 2/20 | 0.51 |
| ▸ | GSK3B | P49841 | 2/20 | 0.51 |
| ▸ | PRKX | P51817 | 2/20 | 0.51 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.51 |
| ▸ | CIT | O14578 | 1/20 | 0.51 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.51 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4685637 | 0.95 | ROCK1 (0.53) | AKT1ROCK1RPS6KA1AKT2AKT3 | |
| SCHEMBL4687918 | 0.91 | AKT1 (0.52) | AKT1ROCK1RPS6KA1AKT2AKT3 | |
| SCHEMBL690257 | 0.90 | ROCK1 (0.54) | AKT1ROCK1RPS6KA1AKT2AKT3 | |
| SCHEMBL3487842 | 0.87 | ROCK1 (0.52) | AKT1ROCK1RPS6KA1AKT2AKT3 | |
| SCHEMBL3487689 | 0.86 | SLC2A1 (0.49) | AKT1ROCK1RPS6KA1AKT2AKT3 | |
| SCHEMBL10053689 | 0.85 | AKT1 (0.72) | AKT1ROCK1RPS6KA1AKT2AKT3 | |
| SCHEMBL4687940 | 0.85 | SLC2A1 (0.50) | AKT1ROCK1RPS6KA1AKT2AKT3 | |
| SCHEMBL5088703 | 0.85 | SLC2A1 (0.50) | AKT1ROCK1RPS6KA1AKT2AKT3 | |
| Formic Acid SCHEMBL691292 | 0.85 | AKT1 (0.66) | AKT1ROCK1RPS6KA1AKT2AKT3 | |
| SCHEMBL3488394 | 0.84 | SLC2A1 (0.49) | AKT1ROCK1RPS6KA1AKT2AKT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009138229-A1 | METHODS FOR THE IDENTIFICATION OF PARP INTERACTING MOLECULES AND FOR PURIFICATION OF PARP PROTEINS | CELLZOME AG (DE) | 2009-11-19 | — | — | WO | disclosed |
| EP-1653961-A4 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORP (US) | 2009-04-01 | — | — | EP | disclosed |
| EP-1653961-A1 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2006-05-10 | — | — | EP | disclosed |
| WO-2005011700-A1 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2005-02-10 | — | — | WO | disclosed |