Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC2A1 | P11166 | 1/20 | 0.50 |
| ▸ | AKT1 | P31749 | 17/20 | 0.47 |
| ▸ | RPS6KA1 | Q15418 | 14/20 | 0.47 |
| ▸ | RPS6KA5 | O75582 | 9/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 16/20 | 0.46 |
| ▸ | AKT2 | P31751 | 7/20 | 0.46 |
| ▸ | AKT3 | Q9Y243 | 5/20 | 0.46 |
| ▸ | CIT | O14578 | 1/20 | 0.44 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.44 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.44 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.44 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | ULK1 | O75385 | 1/20 | 0.44 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.44 |
| ▸ | SMC2 | O95347 | 1/20 | 0.44 |
| ▸ | LATS1 | O95835 | 1/20 | 0.44 |
| ▸ | PAK4 | O96013 | 1/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5088703 | 1.00 | SLC2A1 (0.50) | SLC2A1AKT1RPS6KA1RPS6KA5ROCK1 | |
| SCHEMBL3487998 | 0.91 | SLC2A1 (0.47) | SLC2A1AKT1RPS6KA1RPS6KA5ROCK1 | |
| SCHEMBL4685637 | 0.87 | ROCK1 (0.53) | SLC2A1AKT1RPS6KA1RPS6KA5ROCK1 | |
| SCHEMBL3487689 | 0.86 | SLC2A1 (0.49) | SLC2A1AKT1RPS6KA1RPS6KA5ROCK1 | |
| SCHEMBL4687918 | 0.85 | AKT1 (0.52) | SLC2A1AKT1RPS6KA1RPS6KA5ROCK1 | |
| SCHEMBL4066386 | 0.85 | AKT1 (0.56) | SLC2A1AKT1RPS6KA1RPS6KA5ROCK1 | |
| SCHEMBL3488394 | 0.82 | SLC2A1 (0.49) | SLC2A1AKT1RPS6KA1RPS6KA5ROCK1 | |
| SCHEMBL5053515 | 0.79 | AKT1 (0.51) | SLC2A1AKT1RPS6KA1RPS6KA5ROCK1 | |
| SCHEMBL13461431 | 0.78 | AKT1 (0.54) | AKT1RPS6KA1RPS6KA5ROCK1AKT2 | |
| SCHEMBL3487842 | 0.78 | ROCK1 (0.52) | SLC2A1AKT1RPS6KA1RPS6KA5ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1948188-A2 | INHIBITORS OF AKT ACTIVITY | SmithKline Beecham Corporation (US) | 2008-07-30 | — | — | EP | disclosed |
| WO-2007058850-A2 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-05-24 | — | — | WO | disclosed |