Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 16/20 | 0.64 |
| ▸ | MARK3 | P27448 | 3/20 | 0.64 |
| ▸ | MARK4 | Q96L34 | 2/20 | 0.64 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.64 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.62 |
| ▸ | ULK1 | O75385 | 5/20 | 0.56 |
| ▸ | ULK2 | Q8IYT8 | 5/20 | 0.56 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.54 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.54 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.54 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.54 |
| ▸ | SIK1 | P57059 | 1/20 | 0.54 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.54 |
| ▸ | MELK | Q14680 | 1/20 | 0.54 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.54 |
| ▸ | NUAK2 | Q9H093 | 1/20 | 0.54 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.54 |
| ▸ | MARK1 | Q9P0L2 | 1/20 | 0.54 |
| ▸ | SIK3 | Q9Y2K2 | 1/20 | 0.54 |
| ▸ | CDK2 | P24941 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13431826 | 0.90 | TBK1 (0.77) | TBK1MARK3MARK4STK17APDPK1 | |
| SCHEMBL13431828 | 0.90 | TBK1 (0.79) | TBK1MARK3MARK4STK17APDPK1 | |
| SCHEMBL3388920 | 0.89 | TBK1 (0.59) | TBK1MARK3MARK4STK17APDPK1 | |
| Hydrochloric Acid SCHEMBL3382461 | 0.88 | TBK1 (0.58) | TBK1MARK3MARK4STK17APDPK1 | |
| SCHEMBL3387851 | 0.88 | TBK1 (0.59) | TBK1MARK3MARK4STK17APDPK1 | |
| SCHEMBL13431807 | 0.87 | TBK1 (0.80) | TBK1MARK3MARK4STK17APDPK1 | |
| SCHEMBL3388911 | 0.85 | TBK1 (0.55) | TBK1MARK3MARK4STK17APDPK1 | |
| SCHEMBL13431757 | 0.84 | TBK1 (0.79) | TBK1MARK3MARK4STK17APDPK1 | |
| SCHEMBL13431796 | 0.82 | TBK1 (0.58) | TBK1MARK3MARK4STK17APDPK1 | |
| Trifluoroacetic Acid SCHEMBL3387029 | 0.82 | TBK1 (0.72) | TBK1MARK3MARK4STK17APDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009122180-A1 | PYRIMIDINE DERIVATIVES CAPABLE OF INHIBITING ONE OR MORE KINASES | MEDICAL RESEARCH COUNCIL (GB) | 2009-10-08 | — | — | WO | disclosed |