SCHEMBL4067248

SCHEMBL4067248

COc1cc(C)c(C#N)c(Cl)n1.Cc1cc(Cl)nc(Cl)c1C#N

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RECQL P46063 1/20 0.59
L3MBTL1 Q9Y468 3/20 0.47
POLB P06746 3/20 0.38
TSHR P16473 2/20 0.38
MAPK1 P28482 1/20 0.38
KDM4E B2RXH2 6/20 0.37
ALDH1A1 P00352 5/20 0.37
KMT2A Q03164 4/20 0.36
HPGD P15428 3/20 0.36
MEN1 O00255 3/20 0.36
GAA P10253 2/20 0.36
HSD17B10 Q99714 1/20 0.36
MAPT P10636 1/20 0.35
CACNA1B Q00975 1/20 0.35
APBA1 Q02410 1/20 0.35
APOBEC3G Q9HC16 1/20 0.35
KDM1A O60341 1/20 0.35
CYP1A2 P05177 1/20 0.35
CYP2C9 P11712 1/20 0.35
CYP2C19 P33261 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4071901 0.94 RECQL (0.67) RECQLL3MBTL1POLBTSHRMAPK1
SCHEMBL17164107 0.91 RECQL (0.70) RECQLL3MBTL1POLBTSHRMAPK1
SCHEMBL29496331 0.87 L3MBTL1 (0.57) RECQLL3MBTL1POLBTSHRMAPK1
SCHEMBL534956 0.87 L3MBTL1 (0.57) RECQLL3MBTL1POLBTSHRMAPK1
SCHEMBL4071963 0.77 RECQL (0.67) RECQLL3MBTL1POLBTSHRMAPK1
SCHEMBL4073630 0.76 RECQL (0.71) RECQLL3MBTL1POLBTSHRMAPK1
SCHEMBL2911052 0.76 L3MBTL1 (0.48) RECQLL3MBTL1POLBTSHRMAPK1
SCHEMBL2906258 0.76 RECQL (0.45) RECQLL3MBTL1POLBTSHRMAPK1
SCHEMBL5377959 0.75 RECQL (1.00) RECQLPOLBTSHRMAPK1KDM4E
SCHEMBL20241602 0.75 KDM4E (0.44) RECQLL3MBTL1POLBMAPK1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1706412-A4 NOVEL PYRIDINE DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND A PHARMACEUTICAL COMPOSITION CONTAINING THE SAME SK CHEMICALS CO LTD (KR) 2009-03-18 EP disclosed
EP-1706412-A1 NOVEL PYRIDINE DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND A PHARMACEUTICAL COMPOSITION CONTAINING THE SAME SK Chemicals, Co., Ltd. (KR) 2006-10-04 EP disclosed
WO-2005063768-A1 NOVEL PYRIDINE DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND A PHARMACEUTICAL COMPOSITION CONTAINING THE SAME SK CHEMICALS, CO., LTD. (KR) 2005-07-14 WO disclosed