Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | STS | P08842 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1338962 | 1.00 | JAK2 (0.41) | JAK2JAK1ATMNR1H2NR1H3 | |
| SCHEMBL2933059 | 1.00 | JAK2 (0.41) | JAK2JAK1ATMNR1H2NR1H3 | |
| SCHEMBL2933063 | 1.00 | JAK2 (0.41) | JAK2JAK1ATMNR1H2NR1H3 | |
| SCHEMBL496466 | 0.94 | JAK2 (0.39) | JAK2JAK1ATMNR1H2NR1H3 | |
| SCHEMBL496187 | 0.88 | KMT2A (0.41) | JAK2JAK1ATMNR1H2NR1H3 | |
| SCHEMBL29997881 | 0.85 | NR1H2 (0.48) | JAK2JAK1NR1H2NR1H3STS | |
| SCHEMBL29997304 | 0.85 | NR1H2 (0.48) | JAK2JAK1NR1H2NR1H3STS | |
| SCHEMBL25678532 | 0.80 | LMNA (0.49) | ABCB1L3MBTL1KEAP1NFE2L2LMNA | |
| SCHEMBL3636540 | 0.78 | HTT (0.40) | HDAC8KMT2AL3MBTL1DPP4LMNA | |
| SCHEMBL15600175 | 0.78 | NR1H2 (0.37) | NR1H2NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079690-A2 | 3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES | Actelion Pharmaceuticals Ltd. (CH) | 2009-07-22 | — | — | EP | disclosed |
| WO-2008038251-A2 | 3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2008-04-03 | — | — | WO | disclosed |